Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization

Abstract

Conducting safety evaluations of new drugs using conscious animals has been a specialty of our working group for thirty years. In this article, we review the various technical challenges and solutions dealt with over the years to improve both the data quality and the well being of our animal subjects. Of particular interest for us has been the use of telemetry-based data acquisition for conducting studies on cardiovascular (CV) function. This includes the evolving technical aspects of the studies, as well as the development of new applications that take advantage of this technical approach.

Keywords: Arterial blood pressure; Cardiovascular drug safety; Dog; ECG; Guinea pig; Heart rate; Hemodynamic; Minipig; Mouse; Myocardial contractility; Primate; QT duration; Rat; Telemetry.