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Review
. 2023 Jul;107(4):763-780.
doi: 10.1016/j.mcna.2023.03.011. Epub 2023 Apr 15.

Updates in Cardiorenal Syndrome

Wendy McCallum  1 , Jeffrey M Testani  2
Affiliations
Review

Updates in Cardiorenal Syndrome

Wendy McCallum et al. Med Clin North Am. 2023 Jul.

Abstract

Cardiorenal syndrome is a term that refers to a collection of disorders involving both the heart and kidneys, encompassing multi-directional pathways between the 2 organs mediated through low arterial perfusion, venous congestion, and neurohormonal activation. The pathophysiology is complex and includes hemodynamic and neurohormonal changes, but inconsistent findings from recent studies suggest this is very heterogenous disorder. Management for ADHF remains focused on decongestion and neurohormonal blockade to overcome the intense sodium and fluid avidity of the CRS.

Keywords: Acute decompensated heart failure; Cardiorenal syndrome; Neurohormonal activation; Venous congestion.

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References

    1. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1789–1858. doi:10.1016/S0140-6736(18)32279-7 - DOI - PMC - PubMed
    1. Damman K, Valente MAE, Voors AA, O’Connor CM, van Veldhuisen DJ, Hillege HL. Renal impairment, worsening renal function, and outcome in patients with heart failure: an updated meta-analysis. Eur Heart J. 2014;35(7):455–469. doi:10.1093/eurheartj/eht386 - DOI - PubMed
    1. Fonarow GC, Adams KF, Abraham WT, Yancy CW, Boscardin WJ, ADHERE Scientific Advisory Committee, Study Group, and Investigators. Risk stratification for in-hospital mortality in acutely decompensated heart failure: classification and regression tree analysis. JAMA. 2005;293(5):572–580. doi:10.1001/jama.293.5.572 - DOI - PubMed
    1. Hillege HL, Nitsch D, Pfeffer MA, et al. Renal function as a predictor of outcome in a broad spectrum of patients with heart failure. Circulation. 2006;113(5):671–678. doi:10.1161/CIRCULATIONAHA.105.580506 - DOI - PubMed
    1. Forman DE, Butler J, Wang Y, et al. Incidence, predictors at admission, and impact of worsening renal function among patients hospitalized with heart failure. J Am Coll Cardiol. 2004;43(1):61–67. doi:10.1016/j.jacc.2003.07.031 - DOI - PubMed