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Review
. 2023 Aug;238(8):1641-1650.
doi: 10.1002/jcp.31047. Epub 2023 Jun 1.

Palmitoylation in apoptosis

Peiyao Li  1 , Xiaoyi Gong  1 , Lei Yuan  1 , Lina Mu  1 , Qian Zheng  1 , Hui Xiao  1 , Hui Wang  1
Affiliations
Review

Palmitoylation in apoptosis

Peiyao Li et al. J Cell Physiol. 2023 Aug.

Abstract

Palmitoylation, a critical lipid modification of proteins, is involved in various physiological processes such as altering protein localization, transport, and stability, which perform essential roles in protein function. Palmitoyltransferases are specific enzymes involved in the palmitoylation modification of substrates. S-palmitoylation, as the only reversible palmitoylation modification, is able to be deacylated by deacyltransferases. As an important mode of programmed cell death, apoptosis functions in the maintenance of organismal homeostasis as well as being associated with inflammatory and immune diseases. Recently, studies have found that palmitoylation and apoptosis have been demonstrated to be related in many human diseases. In this review, we will focus on the role of palmitoylation modifications in apoptosis.

Keywords: apoptosis; deacyltransferases; palmitoylation; palmitoyltransferases; protein modification.

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References

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