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Review
. 2023 May 22:2023:4563797.
doi: 10.1155/2023/4563797. eCollection 2023.

Cholera Infection Risks and Cholera Vaccine Safety in Pregnancy

Pamela El Hayek  1   2 , Myriam Boueri  1 , Leah Nasr  1 , Christine Aoun  1 , Edouard Sayad  3 , Karl Jallad  1   2
Affiliations
Review

Cholera Infection Risks and Cholera Vaccine Safety in Pregnancy

Pamela El Hayek et al. Infect Dis Obstet Gynecol. .

Abstract

Introduction: Discuss the impact of cholera infection on pregnant women, fetus, and neonates and review the safety of cholera vaccines in pregnancy.

Methods: This study was carried out as a narrative review during November 2022. A thorough literature review was conducted on the following databases: PubMed, Scopus, SciELO, CINAHL, Web of Science, and ScienceDirect. The following parameters were assessed from the included studies: type of cholera vaccine, cholera symptoms, cholera treatment, effect of cholera on pregnancy, effect of cholera treatment on pregnancy, effect of cholera vaccine on pregnancy, risk factors for fetuses and neonates, and prevention of cholera. The authors independently extracted data from the 24 included studies.

Results: Cholera infection is a serious threat on pregnancy as it could lead to increased stillbirths and neonatal death. Fetal death was shown to occur mainly in the third trimester as most of the pregnant women infected with cholera had spontaneous abortions even after controlling for other confounding variables such as maternal age, dehydration level, and vomiting. Neonatal death was attributed mainly to congenital malformations and low Apgar scores with no improvements. Besides, cholera vaccines have shown to be safe in pregnancy and have proven to lower fetal and neonatal malformations among vaccinated compared to nonvaccinated pregnant women.

Conclusion: This narrative summarizes the different complications due to cholera infection in pregnancy. It also reviews the safety of cholera vaccine administration in pregnant women.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The PRISMA flow diagram of literature screening for cholera during pregnancy.
See this image and copyright information in PMC

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