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Case Reports
. 2023 Mar 8;24(3):192-193.
doi: 10.1002/jgf2.612. eCollection 2023 May.

Pancreatic metastasis from lung adenocarcinoma

Naoki Aoyama  1 , Tetsuro Inokuma  2 , Yuki Nakanishi  1 , Akihisa Fukuda  1
Affiliations
Case Reports

Pancreatic metastasis from lung adenocarcinoma

Naoki Aoyama et al. J Gen Fam Med. .

Abstract

TTF-1 is a highly useful marker to assist in differentiating between pulmonary and nonpulmonary, nonthyroid adenocarcinomas. Our case shows that TTF-1 is highly useful in differentiating between pancreatic metastasis from lung adenocarcinoma and primary pancreatic cancer, especially when the clinical course and imaging findings are not helpful for differentiating them.

Keywords: gastrointestinal medicine; internal medicine; respiratory disease.

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Conflict of interest statement

The authors have stated explicitly that there are no conflicts of interest in connection with this article.

Figures

FIGURE 1
FIGURE 1
A fluorodeoxyglucose‐positron emission tomography (FDG‐PET) shows abnormal accumulation in the pancreatic head (A). Contrast‐enhanced computed tomography (CE‐CT) shows a 7 mm hypovascular mass (B). Endoscopic ultrasound (EUS) demonstrates an irregular hypoechoic mass with the dilation of the main pancreatic duct caudal to the mass (C).
FIGURE 2
FIGURE 2
Hematoxylin and eosin (H&E) staining reveals adenocarcinoma (A), which resembled the histology of primary lung adenocarcinoma (B). Immunohistochemistry shows the positive expression for thyroid transcription factor‐1 (TTF‐1) (C).
See this image and copyright information in PMC

References

    1. Sweeney AD, Wu MF, Hilsenbeck SG, Brunicardi FC, Fisher WE. Value of pancreatic resection for cancer metastatic to the pancreas. J Surg Res. 2009;156(2):189–98. - PubMed
    1. Suzuki A, Shijubo N, Yamada G, Ichimiya S, Satoh M, Abe S, et al. Napsin A is useful to distinguish primary lung adenocarcinoma from adenocarcinomas of other organs. Pathol Res Pract. 2005;201(8–9):579–86. - PubMed
    1. Ordonez NG. Value of thyroid transcription factor‐1 immunostaining in tumor diagnosis: a review and update. Appl Immunohistochem Mol Morphol. 2012;20(5):429–44. - PubMed

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