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Review
. 2023 May 16:10:1188752.
doi: 10.3389/fvets.2023.1188752. eCollection 2023.

Phytochemicals: potential alternative strategy to fight Salmonella enterica serovar Typhimurium

Abdulaziz M Almuzaini  1
Affiliations
Review

Phytochemicals: potential alternative strategy to fight Salmonella enterica serovar Typhimurium

Abdulaziz M Almuzaini. Front Vet Sci. .

Abstract

The rise of multidrug resistant (MDR) microorganisms is a great hazard worldwide and has made it difficult to treat many infectious diseases adequately. One of the most prevalent causes of outbreaks of foodborne illness worldwide is Salmonella. The ability of this and other harmful bacteria to withstand antibiotics has recently proven crucial to their effective control. Since the beginning of time, herbal medicines and phytochemicals have been employed for their potent antibacterial action and there is a growing trend toward the production of plant based natural products for the prevention and treatment of pathogenic infections. Numerous phytochemicals have been proven effective against the molecular determinants responsible for attaining drug resistance in pathogens like efflux pumps, membrane proteins, bacterial cell communications and biofilms. The medicinal plants having antibacterial activity and antibiotics combination with phytochemicals have shown synergetic activity against Salmonella enterica serovar Typhimurium. The inhibitory effects of tannins on rumen proteolytic bacteria can be exploited in ruminant nutrition. Improved control of the rumen ecology and practical use of this feed additive technology in livestock production will be made possible by a better knowledge of the modulatory effects of phytochemicals on the rumen microbial populations in combination with fermentation. This review focuses on the development of antibacterial resistance in Salmonella, the mechanism of action of phytochemicals and the use of phytochemicals against S. enterica serovar Typhimurium. The advances and potential future applications of phytochemicals in the fight against resistant are also discussed.

Keywords: Salmonella; antimicrobial resistance; immune response; livestock; plant extract.

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Conflict of interest statement

The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Systemic infection routes of Salmonella spp. and potential mechanisms of antibacterial actions of tannins (Retrieved from bio render).
Figure 2
Figure 2
Phytochemicals are antibiotic alternatives and their mode of action (Retrieved from bio render).
See this image and copyright information in PMC

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