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Review
. 2023 Sep;25(9):955-963.
doi: 10.1007/s11912-023-01426-0. Epub 2023 Jun 1.

Vascular Inflammation, Cancer, and Cardiovascular Diseases

George S Prousi  1 , Amogh M Joshi  2 , Varun Atti  3 , Daniel Addison  4 , Sherry-Ann Brown  5 , Avirup Guha  6 , Brijesh Patel  7
Affiliations
Review

Vascular Inflammation, Cancer, and Cardiovascular Diseases

George S Prousi et al. Curr Oncol Rep. 2023 Sep.

Abstract

Purpose of review: Cancer and cardiovascular disease are among the leading causes of morbidity and mortality in the USA. Cancer and cardiovascular disease have inflammatory underpinnings that have been associated with both the development and progression of these disease states.

Recent findings: Inflammatory signaling has been found to be a critical event in both cardiovascular disease and cancer formation and progression. Further, many chemotherapeutic agents potentiate inflammation exacerbating existing cardiovascular disease or leading to its presence. The exact mechanisms of these interactions remain poorly understood. The proinflammatory milieu observed in both cancer and cardiovascular disease likely plays an important role in the development and potentiation of both conditions. Further evaluation of this relationship will be critical in the development of new diagnostic and therapeutic modalities.

Keywords: Cardio-oncology; Cardiotoxicity; Endothelial dysfunction; Inflammation.

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Conflict of interest statement

Conflict of Interest The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Preexisting comorbidities, inflammatory state from cancer and antineoplastic agents can interact and contribute to vascular inflammation leading to vasculotoxicity. The environment can lead to premature cardiovascular outcomes
Fig. 2
Fig. 2
This illustration summarizes vasculotoxicity associated with antineoplastic agents. ICI, immune checkpoint inhibitors; MTI, microtubule inhibitors; TKI, tyrosine kinase inhibitors; VEGF, vascular endothelial growth factor
See this image and copyright information in PMC

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