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. 2023 Jun 1;19(6):e1011399.
doi: 10.1371/journal.ppat.1011399. eCollection 2023 Jun.

It takes two to tango: How immune responses and metabolic changes jointly shape cardiac Chagas disease

Azadeh Nasuhidehnavi  1 , Laura-Isobel McCall  1   2   3
Affiliations

It takes two to tango: How immune responses and metabolic changes jointly shape cardiac Chagas disease

Azadeh Nasuhidehnavi et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Cross-regulation of cardiac metabolic pathways by immune cell responses and Trypanosoma cruzi in the heart.
Production of inflammatory mediators including IFN-γ, IFN-α, TGF-β, and NO can affect the metabolic profile of cardiac tissue, as can T. cruzi itself. Parasite mediators of cardiac metabolic modulation are still to be discovered. Created with BioRender.com. IFN-α, interferon-α; IFN-γ, interferon-γ; NO, nitric oxide; TCA, tricarboxylic acid; TGF-β, transforming growth factor-β.
See this image and copyright information in PMC

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