Outcomes with molecularly targeted agents as salvage therapy following frontline venetoclax + hypomethylating agent in adults with acute myeloid leukemia: A multicenter retrospective analysis
- PMID: 37263072
- DOI: 10.1016/j.leukres.2023.107331
Outcomes with molecularly targeted agents as salvage therapy following frontline venetoclax + hypomethylating agent in adults with acute myeloid leukemia: A multicenter retrospective analysis
Keywords: AML; Acute myeloid leukemia; Enasidenib; Gilteritinib; HMA; Hypomethylating agents; Ivosidenib; Outcomes; Targeted therapies; Venetoclax.
Conflict of interest statement
Declaration of Competing Interest VK, TA, SL, JG, EC, and KL report no conflicts of interest. BAJ: Consultant/advisor for AbbVie, BMS, Daiichi Sankyo, Genentech, Gilead, GlycoMimetics, Jazz, Kymera, Pfizer, Rigel, Servier, and Takeda; protocol steering committee for GlycoMimetics; data monitoring committee for Gilead; travel reimbursement/support from AbbVie and Rigel; institutional research funding from AbbVie, Amgen, Aptose, AROG, BMS, Celgene, Daiichi Sankyo, F. Hoffmann-La Roche, Forma, Forty-Seven, Genentech/Roche, Gilead, GlycoMimetics, Hanmi, Immune-Onc, Incyte, Jazz, Loxo Oncology, Pfizer, Pharmacyclics, Sigma Tau, and Treadwell. DAP: Consultant for Abbvie, BMS, and Rigel; research funding from Abbvie. ET: Consultant/advisor for Abbvie, Astellas, Daiichi-Sankyo, and Servier; research funding from Prelude Therapeutics, Schrodinger, Incyte, and Astra-Zeneca. TZ: Consultant: Abbvie and Servier. Research funding: BMS. GNM: Research funding: Forty Seven, Jazz, Astex, Glycomimetics, Gilead, ImmuneOnc, Syndax. Consultancy: Stemline, Pfizer, Macrogenics, Genentech, BMS/Celgene, Astellas, Agios, Abbvie, and Servier.
Comment on
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Efficacy of FLT3 and IDH1/2 inhibitors in patients with acute myeloid leukemia previously treated with venetoclax.Leuk Res. 2022 Nov;122:106942. doi: 10.1016/j.leukres.2022.106942. Epub 2022 Aug 29. Leuk Res. 2022. PMID: 36108424
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