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Review
. 2023 Dec;38(1):2219868.
doi: 10.1080/14756366.2023.2219868.

Recombinant ferritins for multimodal nanomedicine

Yihao Li  1 , Haoyu Gao  1 , Eugenie Nepovimova  2 , Qinghua Wu  1   2 , Vojtech Adam  3 , Kamil Kuca  2   4
Affiliations
Review

Recombinant ferritins for multimodal nanomedicine

Yihao Li et al. J Enzyme Inhib Med Chem. 2023 Dec.

Abstract

In all living organisms, ferritins are a group of proteins important for maintaining iron homeostasis. Increasing amount of studies has shown that recombinant ferritins can be widely used in multimodal nanomedicine, especially for anticancer treatment and vaccination. Recombinant particles prepared by fusing viral proteins and ferritin subunits produce a better immune response and higher antibody titres. Moreover, actively-targeted ferritin nanoparticles can recognise receptors and deliver natural or chemical drugs specifically to the tumour tissue. In addition, ferritin-linked or loaded with contrast agents or fluorescent dyes can be used as multimodal particles useful cancer theranostics. In this review, we fully summarised the unitisation of recombinant ferritins in multimodal nanomedicine. The research progress of using recombinant ferritins as nanovaccines, nanozymes, and bioengineered nanocarriers for targeted therapy and bioimaging is emphasised.

Keywords: Ferritin; nanocarrier; nanovaccine; nanozymes; recombinant protein.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
Recombinant ferritin induces high levels of neutralising antibodies.
Figure 2.
Figure 2.
Long-term efficacy of ferritin nanovaccine.
Figure 3.
Figure 3.
Pt-ferritin develops peroxidase activity to improve the tumour hypoxic microenvironment pO2, thus making it more sensitive to chemotherapy and radiotherapy.
Figure 4.
Figure 4.
Thermal stability of recombinant ferritin nanozymes.
Figure 5.
Figure 5.
Targeted inductions of cancer cell apoptosis by recombinant ferritin.
Figure 6.
Figure 6.
Recombinant ferritin delivery of Cyt c induces in APLs cell apoptosis and nanodrug-0504 inhibits proliferation of pancreatic cancer cells.
Figure 7.
Figure 7.
Recombinant ferritin in bone imaging.
See this image and copyright information in PMC

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