Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jun 1;13(1):8928.
doi: 10.1038/s41598-023-36111-6.

The risk of colorectal cancer according to obesity status at four-year intervals: a nationwide population-based cohort study

Ji Yeon Seo  1 , Eun Hyo Jin  1 , Goh Eun Chung  1 , Young Sun Kim  1 , Jung Ho Bae  1 , Jeong Yoon Yim  1 , Kyung-Do Han  2 , Sun Young Yang  3
Affiliations

The risk of colorectal cancer according to obesity status at four-year intervals: a nationwide population-based cohort study

Ji Yeon Seo et al. Sci Rep. .

Abstract

Obesity is a risk factor for colorectal cancer. However, the effect of body weight change on colorectal cancer is uncertain. This study aimed to investigate the relationship between difference in body mass index and the risk of colorectal cancer. In this nationwide population-based cohort study, participants of the national cancer screening program in 2005 and 2009 were enrolled. Difference of body mass index was calculated from screening data from 2005 and 2009. Participants were divided into four groups according to direction of obesity status: non-obese/non-obese, non-obese/obese, obese/non-obese, and obese/obese. The effect of differences in body mass index on colorectal cancer was analyzed. Among 3,858,228 participants, 47,894 (1.24%) participants were newly diagnosed with colorectal cancer during the 9.2 years of follow-up. The incidence of colorectal cancer was higher in the obese/obese group than the non-obese/non-obese group (hazard ratio = 1.08 [1.06-1.11], P trend < 0.001). The men in the obese/obese group had a higher risk of colon cancer than women (hazard ratio = 1.13 [1.10-1.17] in men, and hazard ratio = 1.04 [1.01-1.18] in women, P = 0.001). Persistent obesity was associated with a higher risk of incidence of colorectal cancer.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Incidence of colorectal cancer according to the cumulative obesity burden.
Figure 2
Figure 2
Flow chart of enrollment process in this study.
See this image and copyright information in PMC

References

    1. Sung H, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2021;71:209–249. doi: 10.3322/caac.21660. - DOI - PubMed
    1. Arnold M, et al. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66:683–691. doi: 10.1136/gutjnl-2015-310912. - DOI - PubMed
    1. Li N, et al. Incidence, mortality, survival, risk factor and screening of colorectal cancer: A comparison among China, Europe, and northern America. Cancer Lett. 2021;522:255–268. doi: 10.1016/j.canlet.2021.09.034. - DOI - PubMed
    1. Kim MK, et al. 2014 clinical practice guidelines for overweight and obesity in Korea. Endocrinol. Metab. (Seoul) 2014;29:405–409. doi: 10.3803/EnM.2014.29.4.405. - DOI - PMC - PubMed
    1. Jee SH, et al. Body mass index and cancer risk in Korean men and women. Int. J. Cancer. 2008;123:1892–1896. doi: 10.1002/ijc.23719. - DOI - PubMed