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Comment
. 2023 Dec;20(12):1399-1400.
doi: 10.1038/s41423-023-01044-7. Epub 2023 Jun 2.

PI4P STimulatING innate immune activation: beyond the Golgi

Yi Zheng #  1 , Xuejing Zhang #  1 , Chengjiang Gao  2
Affiliations
Comment

PI4P STimulatING innate immune activation: beyond the Golgi

Yi Zheng et al. Cell Mol Immunol. 2023 Dec.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Cytoplasmic DNA or Mn2+ stimulates cGAS aggregation and its enzymatic activity to catalyze ATP and GTP consumption for the synthesis of 2′3′-cGAMP. 2'3'-cGAMP binds to STING in the endoplasmic reticulum membrane and stimulates its translocation to the Golgi. In the trans-Golgi network (TGN), ARMH3 interacts with STING and recruits PI4KB to synthesize PI4P near STING. Furthermore, PI4P-binding proteins, such as AP-1 and GGA2, direct STING translocation to clathrin-coated vesicles (CCVs), which eventually traffic STING to endosomes, inducing STING activation. Other PI4P-binding proteins, such as lipid transporter proteins, facilitate lipid transportation and establish a lipid environment conducive to STING activation
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References

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