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. 2023 Sep;60(9):1231-1239.
doi: 10.1007/s00592-023-02119-7. Epub 2023 Jun 1.

The correlation between serum uric acid and diabetic kidney disease in adult-onset type 1 diabetes patients in China

Jun Jiang  1   2 , Xiaowan Zhou  2 , Lei Lan  2 , Jianping Weng  3   4 , Wei Ren  5   6
Affiliations

The correlation between serum uric acid and diabetic kidney disease in adult-onset type 1 diabetes patients in China

Jun Jiang et al. Acta Diabetol. 2023 Sep.

Abstract

Background/aim: To assess the correlation between serum uric acid (UA) level and diabetic kidney disease among adult-onset Type 1 diabetes mellitus (T1DM) patients in China.

Methods: A total of 184 patients with adult-onset T1DM between January 2014 and December 2016 were recruited, with demographics and medical data collected. Comparisons were performed between according to different serum UA gender-specific quartiles. Relationship between serum UA level with urinary ACR and eGFR was also assessed.

Results: Median urinary ACR and eGFR were 21.55 [10.79, 45.02] mg/g and 113.86 [88.43, 143.61] ml/min/1.73 m2, respectively. The median UA was 257.4 (208.2-334.8) μmol/L. Participants with higher serum UA levels had higher urinary ACR and lower eGFR than those with lower UA (P < 0.05). Higher serum UA level was significantly associated with higher urinary ACR in Spearman's correlational analysis (P = 0.006) and multiple stepwise regression analysis (P = 0.013). The association between serum UA and urinary ACR was not linear, but showed a curve correlation, which also showed in the sensitivity analysis. Serum UA in the upper gender-specific quartile, was associated with lower eGFR (P < 0.001) and showed an independent negative correlation with eGFR in multiple stepwise regression analysis (P < 0.001).

Conclusions: The serum UA level was negatively correlated with eGFR and had a curve correlation with urinary ACR in adult-onset T1DM patients of China.

Keywords: Adult-onset; Diabetic kidney disease; Serum uric acid; Type 1 diabetes mellitus.

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Conflict of interest statement

On behalf of all authors, the corresponding author states that there is no conflict of interest to disclose.

Figures

Fig. 1
Fig. 1
Serum UA in groups of albuminuria. Data represent median (P25, P75). Participants were categorized as normoalbuminuria (ACR < 30 mg/g), microalbuminuria (ACR 30–299 mg/g), and macroalbuminuria (ACR > 300 mg/g)
Fig. 2
Fig. 2
Correlations with serum UA and A urinary ACR and B eGFR
Fig. 3
Fig. 3
Urinary ACR in gender-specific quartiles of serum uric acid. Data represent the median (P25, P75)
Fig. 4
Fig. 4
eGFR in gender-specific quartiles of serum uric acid. Data represent the median (P25, P75)
See this image and copyright information in PMC

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