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Editorial
. 2023 Jun 2;13(6):1288-1290.
doi: 10.1158/2159-8290.CD-23-0332.

Pancreatic Neoplasms Are Frighteningly Common: A Role for Immune Surveillance?

Megan T Hoffman  1   2 , Stephanie K Dougan  1   2
Affiliations
Editorial

Pancreatic Neoplasms Are Frighteningly Common: A Role for Immune Surveillance?

Megan T Hoffman et al. Cancer Discov. .

Abstract

Carpenter and colleagues analyze organ donors to find that pancreatic intraepithelial neoplasia (PanIN), the precursor lesions of pancreatic ductal adenocarcinoma, are highly prevalent in the average healthy adult starting from a young age. Why these precursor lesions do not progress to cancer in most people is a mystery. See related article by Carpenter et al., p. 1324 (1).

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  • Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions.
    Carpenter ES, Elhossiny AM, Kadiyala P, Li J, McGue J, Griffith BD, Zhang Y, Edwards J, Nelson S, Lima F, Donahue KL, Du W, Bischoff AC, Alomari D, Watkoske HR, Mattea M, The S, Espinoza CE, Barrett M, Sonnenday CJ, Olden N, Chen CT, Peterson N, Gunchick V, Sahai V, Rao A, Bednar F, Shi J, Frankel TL, Pasca di Magliano M. Carpenter ES, et al. Cancer Discov. 2023 Jun 2;13(6):1324-1345. doi: 10.1158/2159-8290.CD-23-0013. Cancer Discov. 2023. PMID: 37021392 Free PMC article.

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