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Review
. 2023 Dec;30(1):2219419.
doi: 10.1080/10717544.2023.2219419.

Therapeutic applications of contact lens-based drug delivery systems in ophthalmic diseases

Lianghui Zhao  1   2 , Jike Song  2   3 , Yongle Du  1 , Cong Ren  2   3 , Bin Guo  1   2   3 , Hongsheng Bi  1   2   3
Affiliations
Review

Therapeutic applications of contact lens-based drug delivery systems in ophthalmic diseases

Lianghui Zhao et al. Drug Deliv. 2023 Dec.

Abstract

Traditional ophthalmic drugs, such as eye drops, gels and ointments, are accompanied by many problems, including low bioavailability and potential drug side effects. Innovative ophthalmic drug delivery systems have been proposed to overcome the limitations associated with traditional formulations. Recently, contact lens-based drug delivery systems have gained popularity owing to their advantages of sustained drug delivery, prolonged drug retention, improved bioavailability, and few drug side effects. Various methods have been successfully applied to drug-loaded contact lenses and prolonged the drug release time, such as chemical crosslinking, material embedding, molecular imprinting, colloidal nanoparticles, vitamin E modification, drug polymer film/coating, ion ligand polymerization systems, and supercritical fluid technology. Contact lens-based drug delivery systems play an important role in the treatment of multifarious ophthalmic diseases. This review discusses the latest developments in drug-loaded contact lenses for the treatment of ophthalmic diseases, including preparation methods, application in ophthalmic diseases and future prospects.

Keywords: Drug delivery; contact lens; ophthalmic diseases; polymer material.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1.
Figure 1.
Application of novel contact lenses in ophthalmic diseases.
See this image and copyright information in PMC

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