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. 2023 May 17:14:1131105.
doi: 10.3389/fpsyt.2023.1131105. eCollection 2023.

Association of serum alkaline phosphatase and depression in US adults: a population-based cross-sectional study

Yujiang Liang  1 , Yafei Mao  1   2 , Weizhong Liang  3 , Liping Liang  1 , Min Suo  1 , Juan Xue  1 , Hui Yang  4
Affiliations

Association of serum alkaline phosphatase and depression in US adults: a population-based cross-sectional study

Yujiang Liang et al. Front Psychiatry. .

Abstract

Background: Depression, a serious public health disorder, is increasingly prevalent worldwide. An association between alkaline phosphatase (ALP) and neurological disorders has been reported. However, data on ALP and depression risk are scarce, which warrants attention.

Methods: We assessed the association between ALP and risk of depression in adults from the 2007-2014 National Health and Nutrition Examination Survey (NHANES). Depression was assessed using the Patient Health Questionnaire-9. Univariate and multivariate logistic regression were used to assess the association between ALP and risk of depression, and subgroup analyses were also performed.

Results: A total of 17,485 participants were included. The prevalence of depression was 9.3% (1,631/17,485) and ALP was significantly associated with the risk of depression when ALP was a categorical variable (quadratic or categorized by 79 U/L) in a multivariate logistic regression model after adjusting for confounding factors (≥79 U/L vs. <79 U/L, adjusted OR, 1.15; 95%CI, 1.02-1.29). Each 1-unit increase in ALP (log2) was associated with a 20% increase in depression prevalence (adjusted OR, 1.20; 95%CI, 1.06-1.36) when ALP was used as a continuous variable. Subgroup analysis showed that ALP was positively associated with the risk of depression with different characteristics.

Conclusion: Our findings suggest that higher alkaline phosphatase levels, even within the normal range, are significantly associated with a higher risk of depression in US adults. Such findings require further prospective studies to provide more evidence.

Keywords: alkaline phosphatase; depression; diabetes; mental health; national health and nutrition examination.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Participants inclusion flowchart.
Figure 2
Figure 2
Subgroup analyses of the serum ALP and depression.
See this image and copyright information in PMC

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