Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 May 17:13:1163289.
doi: 10.3389/fonc.2023.1163289. eCollection 2023.

Pre-diagnostic blood biomarkers for adult glioma

Lily J Andrews  1   2   3 , Philippa Davies  1   2   3 , Christopher Herbert  4 , Kathreena M Kurian  1   2   3   5
Affiliations
Review

Pre-diagnostic blood biomarkers for adult glioma

Lily J Andrews et al. Front Oncol. .

Abstract

Glioma is one of the most common malignant primary brain tumours in adults, of which, glioblastoma is the most prevalent and malignant entity. Glioma is often diagnosed at a later stage of disease progression, which means it is associated with significant mortality and morbidity. Therefore, there is a need for earlier diagnosis of these tumours, which would require sensitive and specific biomarkers. These biomarkers could better predict glioma onset to improve diagnosis and therapeutic options for patients. While liquid biopsies could provide a cheap and non-invasive test to improve the earlier detection of glioma, there is little known on pre-diagnostic biomarkers which predate disease detection. In this review, we examine the evidence in the literature for pre-diagnostic biomarkers in glioma, including metabolomics and proteomics. We also consider the limitations of these approaches and future research directions of pre-diagnostic biomarkers for glioma.

Keywords: early detection; glioblastoma; glioma; liquid biomarkers; pre-diagnostic.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Biomarkers investigated in pre-diagnostic blood of glioma patients. Created with BioRender.com.
See this image and copyright information in PMC

References

    1. Ostrom QT, Gittleman H, Liao P, Vecchione-Koval T, Wolinsky Y, Kruchko C, et al. . CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the united states in 2010–2014. Neuro-oncology (2017) 19(suppl_5):v1–v88. doi: 10.1093/neuonc/nox158 - DOI - PMC - PubMed
    1. Gray E, Butler HJ, Board R, Brennan PM, Chalmers AJ, Dawson T, et al. . Health economic evaluation of a serum-based blood test for brain tumour diagnosis: exploration of two clinical scenarios. BMJ Open (2018) 8(5):e017593. doi: 10.1136/bmjopen-2017-017593 - DOI - PMC - PubMed
    1. Mattox AK, Bettegowda C, Zhou S, Papadopoulos N, Kinzler KW, Vogelstein B. Applications of liquid biopsies for cancer. Sci Trans Med (2019) 11(507):eaay1984. doi: 10.1126/scitranslmed.aay1984 - DOI - PubMed
    1. Howell AE, Zheng J, Haycock PC, McAleenan A, Relton C, Martin RM, et al. . Use of mendelian r andomization for I dentifying r isk f actors for b rain T umors. Front Genet (2018) 9:525. doi: 10.3389/fgene.2018.00525 - DOI - PMC - PubMed
    1. Wiemels JL, Wiencke JK, Sison JD, Miike R, McMillan A, Wrensch M. History of allergies among adults with glioma and controls. Int J cancer (2002) 98(4):609–15. doi: 10.1002/ijc.10239 - DOI - PubMed

LinkOut - more resources