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Editorial
. 2023 Mar;18(1):67-73.
doi: 10.26574/maedica.2023.18.1.67.

COVID-19 in Pregnant Patients at Term: Evolution of Coagulation Factors in Mild Forms throughout the Pandemic: Conventional Analysis and Logistic Regression

Catalina Filip  1 , Roxana Covali  2 , Demetra Socolov  3 , Ioana Pavaleanu  4 , Alexandru Carauleanu  3 , Ioana Sadiye Scripcariu  3 , Ingrid Andrada Vasilache  3 , Mona Akad  5 , Vasile Lucian Boiculese  6 , Cristina Dimitriu  7 , Tudor Butureanu  4 , Alina Melinte  8 , Cristiana Filip  7 , Radu Florin Popa  1 , Razvan Socolov  4
Affiliations
Editorial

COVID-19 in Pregnant Patients at Term: Evolution of Coagulation Factors in Mild Forms throughout the Pandemic: Conventional Analysis and Logistic Regression

Catalina Filip et al. Maedica (Bucur). 2023 Mar.

Abstract

Aim: The evolution of coagulation factors in pregnant patients infected with SARS-CoV-2 during the pandemic is still debated. However, few studies have been carried out to evaluate the silent alterations of blood values in mild forms of the disease. Methods:A total of 153 pregnant patients with an asymptomatic form of COVID-19 and 306 healthy pregnant patients, who were admitted for delivery in our hospital between April 1, 2020 and March 1, 2022, were studied. The blood values harvested closest to the time of delivery were considered. Results:There was a significant variability in values of fibrinogen, prothrombin time, though these were still within normal limits. Conclusions:Pregnant patients with mild forms of COVID-19 displayed some blood alterations, even if they were asymptomatic for COVID-19.

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Figures

TABLE 1.
TABLE 1.
Mean values of coagulation factors in the study and control groups
TABLE 2.
TABLE 2.
Mean values of coagulation factors values in the four groups of COVID-19 pregnant patients
TABLE 3.
TABLE 3.
P values of significant differences between the four groups of patients, taken two by two, for fibrinogen and prothrombin time values
TABLE 4.
TABLE 4.
Forward selection. Coagulation factors
TABLE 5.
TABLE 5.
Backward elimination. Coagulation factors
TABLE 6.
TABLE 6.
Forward selection. Coagulation factors and time periods
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References

    1. Garcia-Espinoza M, Moreno-Álvarez O, Carranza-Lira S, Caldiño-Soto F. Características clínicas, obstétricas y perinatales de embarazadas mexicanas con Covid-19 (Clinical, obstetric and perinatal characteristics of Mexican pregnant women with COVID-19). Rev Med Inst Mex Seguro Soc. 2022;60:116–128. - PMC - PubMed
    1. Jamieson D, Rasmussen S. An update on COVID-19 and pregnancy. Am J Obstet Gynecol. 2022;226:177–186. - PMC - PubMed
    1. Badran E, Darwish R, Khader Y, et al. Adverse pregnancy outcomes during the COVID-19 lockdown. A descriptive study. BMC Pregnancy Childbirth. 2021;21:761. - PMC - PubMed
    1. Pena ALB, Oliveira RA, Severo RG, Simões E Silva AC. COVID-19 Related Coagulopathy: What is Known Up to Now. Curr Med Chem. 2021;28:4207–4225. - PubMed
    1. Donati S, Corsi E, Maraschini A, et al. SARS-CoV-2 infection among hospitalised pregnant women and impact of different viral strains on COVID-19 severity in Italy: a national prospective population-based cohort study. BJOG. 2022;129:221–231. - PMC - PubMed

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