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Review
. 2023 Aug 1;35(4):300-305.
doi: 10.1097/GCO.0000000000000887. Epub 2023 May 19.

Vitamin D and infertility

Samantha Simpson  1 , Lubna Pal  2
Affiliations
Review

Vitamin D and infertility

Samantha Simpson et al. Curr Opin Obstet Gynecol. .

Abstract

Purpose of review: Vitamin D deficiency has been implicated as a contributing factor to a spectrum of reproductive health burden, including difficulty conceiving, pathogenesis of gynaecological disorders such as uterine fibroids and endometriosis, to metabolic and endocrine burden of polycystic ovarian syndrome (PCOS).

Recent findings: There have been recent publications showing that in infertile women who are supplemented with vitamin D, there are higher pregnancy rates; there are improved ovarian reserve parameters in women with diminished ovarian reserve; curtailed fibroid growth in those with uterine myomas; lessened dysmenorrhea in endometriosis patients; and improved menstrual regularity, lowered testosterone, AMH and insulin levels in women with PCOS. In infertile men, sperm parameters, especially motility, are positively correlated with vitamin D serum levels.

Summary: Vitamin D status appears to be relevant to reproductive physiology, and to physiological processes underlying common gynaecological disorders as well as for reproductive success.

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