Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2023 Jul-Aug;49(4):511-514.
doi: 10.1590/S1677-5538.IBJU.2023.9908.

Dapoxetine and premature ejaculation

Affiliations
Editorial

Dapoxetine and premature ejaculation

Rodrigo R Vieiralves et al. Int Braz J Urol. 2023 Jul-Aug.
No abstract available

PubMed Disclaimer

Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1. Ejaculatory physiology and mechanism of action of dapoxetine and other serotonin reuptake inhibitors.

References

    1. Khan HL, Bhatti S, Abbas S, Khan YL, Gonzalez RMM, Aslamkhan M, et al. Serotonin transporter (5-HTTLPR) genotypes and trinucleotide repeats of androgen receptor exert a combinatorial effect on hormonal milieu in patients with lifelong premature ejaculation. Andrology. 2018;6:916–926. - PubMed
    1. Janssen PK, Bakker SC, Réthelyi J, Zwinderman AH, Touw DJ, Olivier B, et al. Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation. J Sex Med. 2009;6:276–284. - PubMed
    1. Hsieh JT, Liu SP, Chang HC, Tsai VF, Chien CT, Yu HJ, et al. The activation of peripheral 5-HT1A receptors can inhibit seminal vesicle contraction: an in vivo animal study. Urology. 2011;78:376–379. - PubMed
    1. Giuliano F, Clément P. Physiology of ejaculation: emphasis on serotonergic control. Eur Urol. 2005;48:408–417. - PubMed
    1. Jenkins LC, Mulhall JP. Delayed orgasm and anorgasmia. Fertil Steril. 2015;104:1082–1088. - PMC - PubMed

Publication types