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. 2023 Jun 1;30(6):745-747.
doi: 10.1016/j.stem.2023.05.006.

We need to talk about lung cancer's cholesterol-hoarding problem

Michael B Fessler  1
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Free article

We need to talk about lung cancer's cholesterol-hoarding problem

Michael B Fessler. Cell Stem Cell. .
Free article

Abstract

Proliferative cells require excess cholesterol to support rapid membrane biogenesis. Using a mutant KRAS mouse model of non-small cell lung cancer, Guilbaud et al. show that lung cancers accumulate cholesterol by locally and distally reprogramming lipid trafficking and that cholesterol-removing interventions may hold promise as a therapeutic strategy.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

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