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Comment
. 2023 Jun 1;30(6):748-749.
doi: 10.1016/j.stem.2023.05.008.

iPSC-based research in ALS precision medicine

Letizia Mazzini  1 , Fabiola De Marchi  2
Affiliations
Free article
Comment

iPSC-based research in ALS precision medicine

Letizia Mazzini et al. Cell Stem Cell. .
Free article

Abstract

Clinical trials in amyotrophic lateral sclerosis (ALS) are challenged by the lack of pre-clinical models and biomarkers of disease onset and progression. In this issue, Morimoto et al. use induced pluripotent stem cell (iPSC)-derived motor neurons from patients with ALS to study therapeutic mechanisms of ropinirole in a clinical trial and identify treatment responders.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery.
    Morimoto S, Takahashi S, Ito D, Daté Y, Okada K, Kato C, Nakamura S, Ozawa F, Chyi CM, Nishiyama A, Suzuki N, Fujimori K, Kondo T, Takao M, Hirai M, Kabe Y, Suematsu M, Jinzaki M, Aoki M, Fujiki Y, Sato Y, Suzuki N, Nakahara J; Pooled Resource Open-Access ALS Clinical Trials Consortium; Okano H. Morimoto S, et al. Cell Stem Cell. 2023 Jun 1;30(6):766-780.e9. doi: 10.1016/j.stem.2023.04.017. Cell Stem Cell. 2023. PMID: 37267913 Clinical Trial.

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