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Comment
. 2023 Jun 1;31(6):641-643.
doi: 10.1016/j.str.2023.05.005.

Mind the gap

Sven Larsen-Ledet  1 , Amelie Stein  2
Affiliations
Free article
Comment

Mind the gap

Sven Larsen-Ledet et al. Structure. .
Free article

Abstract

Amino acid deletions are high-risk, high-reward mutations, yet structural consequences are poorly understood. In this issue of Structure, Woods et al. (2023) individually deleted 65 residues from a small α-helical protein, structurally assayed the 17 soluble variants, and developed a computational model of deletion solubility combining Rosetta and AlphaFold2.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Computational modeling and prediction of deletion mutants.
    Woods H, Schiano DL, Aguirre JI, Ledwitch KV, McDonald EF, Voehler M, Meiler J, Schoeder CT. Woods H, et al. Structure. 2023 Jun 1;31(6):713-723.e3. doi: 10.1016/j.str.2023.04.005. Epub 2023 Apr 28. Structure. 2023. PMID: 37119820 Free PMC article.

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