Docking on SERT reveals new inhibitors

Comment

M Teresa Villanueva. Nat Rev Drug Discov. 2023 Jul.

. 2023 Jul;22(7):536.

doi: 10.1038/d41573-023-00089-7.

No abstract available

Keywords: Brain; Computational biology and bioinformatics; Depression; Drug discovery; Neuroscience; Psychology; Therapeutics.

Comment on

Structure-based discovery of conformationally selective inhibitors of the serotonin transporter.
Singh I, Seth A, Billesbølle CB, Braz J, Rodriguiz RM, Roy K, Bekele B, Craik V, Huang XP, Boytsov D, Pogorelov VM, Lak P, O'Donnell H, Sandtner W, Irwin JJ, Roth BL, Basbaum AI, Wetsel WC, Manglik A, Shoichet BK, Rudnick G. Singh I, et al. Cell. 2023 May 11;186(10):2160-2175.e17. doi: 10.1016/j.cell.2023.04.010. Epub 2023 May 2. Cell. 2023. PMID: 37137306 Free PMC article.

1. Singh, A. et al. Structure-based discovery of conformationally selective inhibitors of the serotonin transporter. Cell 186, 2160–2175.e17 (2023) - PubMed - DOI