Additive influence of exercise pressor reflex activation on Valsalva responses in white and black adults

Abstract

Aim: This study aimed to determine if activation of the exercise pressor reflex exerts additive or redundant influences on the autonomic responses to the Valsalva maneuver (VL), and if these responses differ between White and Black or African American (B/AA) individuals.

Methods: Twenty participants (B/AA n = 10, White n = 10) performed three separate experimental trials. In the first trial, participants performed two VLs in a resting condition. In a second trial, participants performed 5 min of continuous handgrip (HG) exercise at 35% of the predetermined maximal voluntary contraction. In a third and final trial, participants repeated the 5-min bout of HG while also performing two VLs during the 4th and 5th minutes. Beat by beat blood pressure and heart rate (HR) were recorded continuously and the absolute systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), pulse pressure (PP), and heart rate (HR) responses were reported for phases I-IV of each VL.

Results: No significant group by trial interactions or main effects of group were observed for any phase of the VL (all p ≥ 0.36). However, significant main effects of time were observed for blood pressure and heart rate during phases IIa-IV (all p ≤ 0.02). Specifically, the addition of HG exercise exaggerated the hypertensive responses during phases IIb and IV (all p ≤ 0.04) and blunted the hypotensive responses during phases IIa and III (all p ≤ 0.01).

Conclusions: These results suggest that activation of the exercise pressor reflex exerts an additive influence on autonomic responses to the VL maneuver in both White and B/AA adults.

Keywords: Autonomic; Handgrip; Race; Valsalva.