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Review
. 2023 Jul;23(7):361-379.
doi: 10.1007/s11910-023-01274-2. Epub 2023 Jun 3.

Sleep Disorders in Patients with Choreic Syndromes

Félix Javier Jiménez-Jiménez  1 , Hortensia Alonso-Navarro  2 , Elena García-Martín  3 , José A G Agúndez  3
Affiliations
Review

Sleep Disorders in Patients with Choreic Syndromes

Félix Javier Jiménez-Jiménez et al. Curr Neurol Neurosci Rep. 2023 Jul.

Abstract

Purpose of review: Patients with different types of choreic syndromes, specially those with Huntington's (HD) and Wilson's (WD) diseases, report frequent sleep complaints. This review focuses on the main findings of studies addressing the sleep features in these diseases, and other less frequent causes of chorea associated with sleep disorders, including a new syndrome described in the last decade associated with IgLON5 antibodies.

Recent findings: Patients with HD and WD showed a bad quality of sleep and high frequency of insomnia and excessive daytime somnolence. WD patients also showed high scores on a specific scale for rapid eye movement sleep behavior disorders. HD and WD share decreased sleep efficiency and increased REM sleep latencies, percentage of sleep stage N1, and wake after sleep onset (WASO) among their polysomnographic features. Patients with HD and WD showed a high prevalence of different sleep disorders. Patients with other causes of chorea, including neuroacanthocytosis, parasomnia with sleep breathing disorder associated with antibodies to IgLON5, Sydenham's chorea, and choreic syndromes associated to certain genetic mutations show sleep disorders as well.

Keywords: Essential tremor; Excessive daytime somnolence; Insomnia; Restless legs syndrome; Sleep disorders.

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