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. 2023 Dec;45(6):3419-3447.
doi: 10.1007/s11357-023-00807-4. Epub 2023 Jun 3.

Impact of influenza, herpes zoster, and pneumococcal vaccinations on the incidence of cardiovascular events in subjects aged over 65 years: a systematic review

Alexandra Addario  1   2   3   4   5 , Thomas Célarier  6   7 , Bienvenu Bongue  8   9 , Nathalie Barth  6 , Gaëtan Gavazzi  10   11 , Elisabeth Botelho-Nevers  12   13   14   15
Affiliations

Impact of influenza, herpes zoster, and pneumococcal vaccinations on the incidence of cardiovascular events in subjects aged over 65 years: a systematic review

Alexandra Addario et al. Geroscience. 2023 Dec.

Abstract

This systematic review aims to summarize the impact of vaccination against influenza, shingles, and pneumococcus on the incidence on the risk of cardiovascular events in the elderly. This protocol was developed in accordance with PRISMA guidelines. We conducted a literature search and identified all relevant articles published regarding the matter up to September 2022. We retrieved 38 studies (influenza vaccine = 33, pneumococcal vaccine = 5, and zoster vaccine = 2). A total of 28 and 2 studies have shown that influenza and pneumococcal vaccines significantly lower the risk of cardiovascular disease in the elderly. Also, repeated influenza vaccination shows a consistent and dose-dependent protective effect against acute coronary syndromes and stroke. Moreover, dual influenza and pneumococcal vaccination was associated with lower risks of some cardiovascular events (stroke, congestive heart failure, ischemic heart disease, and myocardial infarction). However, the impact of PCV13 on cardiovascular events has not been studied, nor has the currently recommended vaccination schedule (PCV13 + PPV23). As for herpes zoster vaccination, only the protective effect against stroke has been studied with the live attenuated herpes zoster vaccine, but no studies have been conducted with the recombinant subunit herpes zoster vaccine. This review outlines the benefits of the vaccines mentioned above beyond their preventive action on infectious diseases. It is intended for health professionals who wish to inform and advise their elderly patients.

Keywords: Cardiovascular event; Elderly person; Herpes zoster; Influenza; Pneumococci; Vaccine.

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Conflict of interest statement

The authors declare no competing interests.

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Fig. 1
Flow diagram–cardiovascular event
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