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. 2023 Aug;45(8):1943-1951.
doi: 10.1002/hed.27418. Epub 2023 Jun 5.

Outcomes after definitive treatment for cutaneous angiosarcomas of the face and scalp: Reevaluating the role of surgery and radiation therapy

Alison K Yoder  1 , Ahsan S Farooqi  1 , Cort Wernz  2 , Aparna Subramaniam  3 , Vinod Ravi  3 , Ryan Goepfert  4 , Erich M Sturgis  5 , Devarati Mitra  1 , Andrew J Bishop  1 , B Ashleigh Guadagnolo  1
Affiliations

Outcomes after definitive treatment for cutaneous angiosarcomas of the face and scalp: Reevaluating the role of surgery and radiation therapy

Alison K Yoder et al. Head Neck. 2023 Aug.

Abstract

Introduction: We investigated outcomes and prognostic factors for patients treated for cutaneous angiosarcoma (CA).

Methods: We conducted a retrospective review of patients treated for CA of the face and scalp from 1962 to 2019. All received definitive treatment with surgery, radiation (RT), or a combination (S-XRT). The Kaplan-Meier method was used to estimate outcomes. Multivariable analyses were conducted using the Cox proportional hazards model.

Results: For the 143 patients evaluated median follow-up was 33 months. Five-year LC was 51% and worse in patients with tumors >5 cm, multifocal tumors, those treated pre-2000, and with single modality therapy (SMT). These remained associated with worse LC on multivariable analysis. The 5-year disease-specific survival (DSS) for the cohort was 56%. Tumor size >5 cm, non-scalp primary site, treatment pre-2000, and SMT were associated with worse DSS.

Conclusion: Large or multifocal tumors are negative prognostic factors in patients with head and neck CA. S-XRT improved outcomes.

Keywords: angiosarcoma; radiation; surgery.

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Conflict of interest statement

Conflicts of Interest: None of the authors have any conflicts of interest to report

Figures

Figure 1:
Figure 1:
Overall survival (OS) and disease-specific survival (DSS) in entire cohort of patients undergoing definitive treatment for cutaneous head and neck angiosarcoma.
Figure 2:
Figure 2:
Comparing local control (LC) in patients with cutaneous head and neck angiosarcoma who received combined modality therapy (S-XRT) versus single modality therapy (SMT)
See this image and copyright information in PMC

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