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Review
. 2023 May 19:14:1172807.
doi: 10.3389/fneur.2023.1172807. eCollection 2023.

Advanced central nervous system imaging biomarkers in radiologically isolated syndrome: a mini review

Sara Collorone #  1 , Michael A Foster #  1 , Ahmed T Toosy  1
Affiliations
Review

Advanced central nervous system imaging biomarkers in radiologically isolated syndrome: a mini review

Sara Collorone et al. Front Neurol. .

Abstract

Radiologically isolated syndrome is characterised by central nervous system white-matter hyperintensities highly suggestive of multiple sclerosis in individuals without a neurological history of clinical demyelinating episodes. It probably represents the pre-symptomatic phase of clinical multiple sclerosis but is poorly understood. This mini review summarises our current knowledge regarding advanced imaging techniques in radiologically isolated syndrome that provide insights into its pathobiology and prognosis. The imaging covered will include magnetic resonance imaging-derived markers of central nervous system volumetrics, connectivity, and the central vein sign, alongside optical coherence tomography-related metrics.

Keywords: connectivity; magnetic resonance imaging; multiple sclerosis; neurodegeneration; optical coherence tomography; radiologically isolated syndrome.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Advanced imaging features of radiologically isolated syndrome in the central nervous system. Cr, creatinine; CVS, central vein sign; GCIPL, ganglion cell-inner plexiform layer; GM, grey matter; NAA, N-acetyl aspartate; pRNFL, peripapillary retinal nerve fibre layer; WM, white matter.
See this image and copyright information in PMC

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