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Review
. 2022 Sep 5:16:e187430642207060.
doi: 10.2174/18743064-v16-e2207060. eCollection 2022.

The Journey for Lung Cancer Screening where we Stand Today

Ali S Wahla  1 , Zaid Zoumot  1 , Mateen Uzbeck  1 , Jihad Mallat  1 , Redha Souilamas  1 , Irfan Shafiq  1
Affiliations
Review

The Journey for Lung Cancer Screening where we Stand Today

Ali S Wahla et al. Open Respir Med J. .

Abstract

Background: Lung cancer remains a leading cause of cancer mortality worldwide with many patients presenting with advanced disease.

Objective: We reviewed the available literature for lung cancer screening using low dose computed tomography (LDCT). We reviewed the National Lung Screening Trial (NLST), Early Lung Cancer Action Program (ELCAP) and the (Nederlands-Leuvens Longkanker Screenings Onderzoek (NELSON) trials. We also look at different lung cancer risk prediction models that may aid in identifying target populations and also discuss the cost-effectiveness of LDCT screening in different groups of smokers and ex-smokers. Lastly, we discuss recent guideline changes that have occurred in line with new and emerging evidence on lung cancer screening.

Conclusion: LDCT has been shown reduce lung cancer mortality in certain groups of current and former smokers and should be considered to help in the early diagnosis of lung cancer.

Keywords: Cancer; Computed tomography; Evidence; Lung cancer; National lung screening trial (NLST); Screening.

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Conflict of interest statement

All authors declared no conflict of interest.

References

    1. Global Burden of Disease Cancer Collaboration. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol. 2017;3(4):524–548. doi: 10.1001/jamaoncol.2016.5688. - DOI - PMC - PubMed
    1. Ferlay J., Soerjomataram I., Dikshit R., Eser S., Mathers C., Rebelo M., Parkin D.M., Forman D., Bray F. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer. 2015;136(5):E359–E386. doi: 10.1002/ijc.29210. - DOI - PubMed
    1. Lung cancer incidence statistics. Cancer Research UK. 2015. Available from: https://www.cancerresearchuk.org/health-professional/cancer-statistics/s... .
    1. Sheehan D.F., Criss S.D., Chen Y., Eckel A., Palazzo L., Tramontano A.C., Hur C., Cipriano L.E., Kong C.Y. Lung cancer costs by treatment strategy and phase of care among patients enrolled in Medicare. Cancer Med. 2019;8(1):94–103. doi: 10.1002/cam4.1896. - DOI - PMC - PubMed
    1. Tanoue L.T., Tanner N.T., Gould M.K., Silvestri G.A. Lung cancer screening. Am. J. Respir. Crit. Care Med. 2015;191(1):19–33. doi: 10.1164/rccm.201410-1777CI. - DOI - PubMed

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