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. 2023 Aug;132(6):694-703.
doi: 10.1037/abn0000826. Epub 2023 Jun 5.

Preonset predictors of chronic-intermittent depression from early adolescence to early adulthood

Daniel N Klein  1 , Greg Perlman  2 , Scott M Feltman  2 , Roman Kotov  2
Affiliations

Preonset predictors of chronic-intermittent depression from early adolescence to early adulthood

Daniel N Klein et al. J Psychopathol Clin Sci. 2023 Aug.

Abstract

Individuals with prolonged or frequent episodes account for a disproportionate share of the burden of depression. However, there are surprisingly few data on whether individuals at risk for developing chronic-intermittent depression (CID) as opposed to briefer, infrequent depressive episodes (time-limited depression [TLD]) can be distinguished before their first depressive episode. We followed a community sample of 465 never-depressed females on five occasions from age 14 to 20 years and examined whether 18 preonset clinical and psychosocial variables prospectively predicted CID. The CID group accounted for 40% of depressed cases but 84% of the cumulative time depressed in the sample. Participants with CID (n = 60) exhibited significantly higher preonset levels of 16 of the 18 risk factors than the never-depressed group (n = 315). The TLD group (n = 90) had significantly higher preonset levels of nine risk factors than never-depressed participants. Finally, the CID group had significantly higher levels of nine risk factors than the TLD group, five of which were similar in TLD and never-depressed participants. These findings indicate that differences between CID and TLD are evident before onset and suggest that the liability to CID may be both greater than, and somewhat different from, the liability to TLD. Moreover, they suggest that individuals at risk for a malignant course of depression can be targeted for prevention and early intervention. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

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Figures

Figure 1.
Figure 1.
Summary of Comparisons Between Never-Depressed (ND), Time-Limited Depressed (TLD), And Chronic-Intermittent Depressed (CID) Groups on Baseline (Pre-Onset) Risk Factors
See this image and copyright information in PMC

References

    1. American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV). Washington, DC: American Psychiatric Association.
    1. Andreasen NC, Rice J, Endicott J, Reich T, & Coryell W (1986). The family history approach to diagnosis: how useful is it?. Archives of General Psychiatry, 43(5), 421–429. - PubMed
    1. Bagby RM, Parker JD, Joffe RT, & Buis T (1994). Reconstruction and validation of the Depressive Experiences Questionnaire. Assessment, 1(1), 59–68. - PubMed
    1. Baumeister H, & Parker G (2012). Meta-review of depressive subtyping models. Journal of Affective Disorders, 139, 126–140. - PubMed
    1. Brouwer ME, Williams AD, Kennis M, Fu Z, Klein NS, Cuijpers P, & Bockting CL (2019). Psychological theories of depressive relapse and recurrence: A systematic review and meta-analysis of prospective studies. Clinical Psychology Review, 74, 101773. - PubMed