Hydrazine Toxicology
- PMID: 37276286
- Bookshelf ID: NBK592403
Hydrazine Toxicology
Excerpt
Hydrazines (R2N−NR2) are a class of chemical compounds with 2 nitrogen atoms linked by a single covalent bond and may carry up to four alkyl substituents. Organohydrazine compounds and their derivatives produce significant toxicity in human exposures.
Commonly encountered examples include hydrazine, hydrazones, 1,1-dimethylhydrazine, 1,2-dimethylhydrazine, and monomethylhydrazine (MMH). In its pure form, hydrazine (H2N-NH2) is a clear, colorless liquid chemical with an ammonia-like odor.
Throughout this activity, the word "hydrazines" refers to hydrazine, 1,1-dimethylhydrazine, 1,2-dimethylhydrazine, and monomethylhydrazine.
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Sections
- Continuing Education Activity
- Introduction
- Etiology
- Epidemiology
- Pathophysiology
- Toxicokinetics
- History and Physical
- Evaluation
- Treatment / Management
- Differential Diagnosis
- Prognosis
- Complications
- Consultations
- Deterrence and Patient Education
- Pearls and Other Issues
- Enhancing Healthcare Team Outcomes
- Review Questions
- References
References
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- Metabolic sites of hydrazine toxicity. Nutr Rev. 1968 Feb;26(2):56-8. - PubMed
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- Choudhary G, Hansen H. Human health perspective on environmental exposure to hydrazines: a review. Chemosphere. 1998 Aug;37(5):801-43. - PubMed
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- Erwin ER, Addison AP, John SF, Olaleye OA, Rosell RC. Pharmacokinetics of isoniazid: The good, the bad, and the alternatives. Tuberculosis (Edinb) 2019 May;116S:S66-S70. - PubMed
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