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Comment
. 2023 Jun;55(6):910-911.
doi: 10.1038/s41588-023-01400-3.

Genes with immune functions modulate key traits associated with Down syndrome in mice

No authors listed
Comment

Genes with immune functions modulate key traits associated with Down syndrome in mice

No authors listed. Nat Genet. 2023 Jun.
No abstract available

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Comment on

  • Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model.
    Waugh KA, Minter R, Baxter J, Chi C, Galbraith MD, Tuttle KD, Eduthan NP, Kinning KT, Andrysik Z, Araya P, Dougherty H, Dunn LN, Ludwig M, Schade KA, Tracy D, Smith KP, Granrath RE, Busquet N, Khanal S, Anderson RD, Cox LL, Estrada BE, Rachubinski AL, Lyford HR, Britton EC, Fantauzzo KA, Orlicky DJ, Matsuda JL, Song K, Cox TC, Sullivan KD, Espinosa JM. Waugh KA, et al. Nat Genet. 2023 Jun;55(6):1034-1047. doi: 10.1038/s41588-023-01399-7. Epub 2023 Jun 5. Nat Genet. 2023. PMID: 37277650 Free PMC article.

References

    1. Antonarakis, S. E. et al. Down syndrome. Nat. Rev. Dis. Primers 6, 9 (2020). A review article summarizing the current state of Down syndrome research. - DOI - PubMed - PMC
    1. Li, Z. et al. Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities. Hum. Mol. Genet. 16, 1359–1366 (2007). A paper describing the Dp16 mouse model of Down syndrome. - DOI - PubMed
    1. Tan, Y. H. et al. Human chromosome 21 dosage: effect on the expression of the interferon induced antiviral state. Science 186, 61–63 (1974). A pioneering paper demonstrating that cells with trisomy 21 are hypersensitive to interferon stimulation. - DOI - PubMed
    1. Maroun, L. E. Interferon action and chromosome 21 trisomy. J. Theor. Biol. 86, 603–606 (1980). An early review article on the potential role of interferon signaling in Down syndrome. - DOI - PubMed
    1. Sullivan, K. D. et al. Trisomy 21 consistently activates the interferon response. eLife 5, e162020 (2016). A paper describing consistent upregulation of interferon signaling in multiple immune and non-immune cell types with trisomy 21. - DOI