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Meta-Analysis
. 2023 Jun 5;21(1):52.
doi: 10.1186/s12969-023-00826-7.

HLA-B*27 is associated with CNO in a European cohort

Daire O'Leary  1   2 , Dalila Ali Al Julandani  3 , Muhammad Zia  4 , Jens Klotsche  5 , Kirsten Minden  5   6 , Marion Roderick  7   8 , Athimalaipet V Ramanan  3   9 , Orla G Killeen  10   4 , Anthony G Wilson  10
Affiliations
Meta-Analysis

HLA-B*27 is associated with CNO in a European cohort

Daire O'Leary et al. Pediatr Rheumatol Online J. .

Abstract

Objectives: To determine the influence of HLA-B27 positivity on risk of developing chronic nonbacterial osteomyelitis (CNO).

Methods: HLA-B*27 genotype was assessed in 3 European CNO populations and compared with local control populations (572 cases, 33,256 controls). Regional or whole-body MRI was performed at diagnosis and follow-up in all cases which reduces the risk of disease misclassification. Genotyping was performed using either next generation DNA sequencing or PCR based molecular typing. Statistical analysis used Fisher's exact test with Bonferroni correction and a fixed effects model for meta-analysis of odds ratios.

Results: HLA-B*27 frequency was higher in all 3 populations compared with local controls (combined odds ratio (OR) = 2.2, p-value = 3 × 10-11). This association was much stronger in male compared with female cases (OR = 1.99, corrected p-value = 0.015). However, the HLA-B*27 status was not statistically significantly associated with co-occurrence of psoriasis, arthritis or inflammatory bowel disease.

Conclusion: Carriage of HLA-B*27 is associated with greater risk of developing CNO, particularly in male cases.

Keywords: CNO; CRMO; Chronic nonbacterial osteomyelitis; HLA; Paediatric rheumatology.

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Conflict of interest statement

No potential conflicts of interest relevant to this article were reported by any of the authors.

Figures

Fig. 1
Fig. 1
HLA-B*27 is associated with CNO. Forest plot of pooled odds ratios using a fixed effects model (p = 3.07 × 10–11)
See this image and copyright information in PMC

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