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. 2023 Dec;25(12):1229-1235.
doi: 10.1080/10286020.2023.2219616. Epub 2023 Jun 6.

Asterosaponins from the starfish Protoreaster nodosus

Le Thi Vien  1 , Tran Thi Hong Hanh  1 , Tran Hong Quang  1 , Nguyen Van Thanh  1 , Nguyen Xuan Cuong  1 , Nguyen Hoai Nam  1 , Thung Do Cong  2 , Phan Van Kiem  1
Affiliations

Asterosaponins from the starfish Protoreaster nodosus

Le Thi Vien et al. J Asian Nat Prod Res. 2023 Dec.

Abstract

Five asterosaponins (1-5), including one new compound named protonodososide (1), were isolated from the methanol extract of the starfish Protoreaster nodosus, after subjecting to various chromatographic separations. The structural elucidation was confirmed by careful analysis of the 1D, 2D NMR, and HR ESI QTOF mass spectra. The cytotoxicity of isolated compounds was evaluated on five human cancer cell lines including HepG2, KB, MCF7, LNCaP, and SK-Mel2.

Keywords: Asteroidea; Protoreaster nodosus; asterosaponins; cytotoxic activity; protonodososide.

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