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. 2023 Jun 6;31(7):379.
doi: 10.1007/s00520-023-07835-y.

Health-related quality of life and use of medication with anticholinergic activity in patients with multiple myeloma

Mariana Sampaio Rodrigues de Lima  1 , Cristiane Aparecida Menezes de Pádua  2 , Paula Lana de Miranda Drummond  3 , Lívia Pena Silveira  4 , Jéssica Soares Malta  2 , Roberta Márcia Marques Dos Santos  5 , Adriano Max Moreira Reis  6
Affiliations

Health-related quality of life and use of medication with anticholinergic activity in patients with multiple myeloma

Mariana Sampaio Rodrigues de Lima et al. Support Care Cancer. .

Abstract

Purpose: Verify the association between anticholinergic burden and health-related quality of life of patients with multiple myeloma.

Methods: Cross-sectional study with multiple myeloma outpatient from a state capital city in southeastern Brazil. Sociodemographic, clinical, and pharmacotherapeutic variables were collected by interview. Clinical data were complemented by medical records. Drugs with anticholinergic activity were identified with Brazilian Anticholinergic Activity Drug Scale. Health-related quality of life scores were obtained using QLQ-C30 and QLQ-MY20 instruments. Mann-Whitney was used to compare the median of the health-related quality of life scale scores and the independent variables. Multivariate linear regression was performed to verify the association between independent variables and health-related quality of life scores.

Results: Two hundred thirteen patients were included, 56.3% had multi-morbidities, and 71.8% used polypharmacy. In all health-related quality of life domains, there were differences between the medians of the polypharmacy variable. A significant difference was identified between the ACh burden and QLQ-C30 and QLQ-MY20 scores. Linear regression identified an association between the use of drugs with anticholinergic activity and the reduction of global status scores (QLQ-C30), functional scale (QLQ-C30), body image (QLQ-MY20), and future perspective (QLQ-MY20). Drugs with anticholinergic activity were associated with increased symptom scores (QLQ-C30 and QLQ-MY20). Polypharmacy was associated with reduction of functioning score and increase of symptom score (QLQ-C30).

Conclusion: Anticholinergic burden in MM patients is associated with lower scores in quality of life domains: global health and symptoms (QLQ-C30) and functional (QLQ-C30 and QLQ-MY20). The presence of polypharmacy is also associated with lower scores for functional scales and symptom scales (QLQ-C30).

Keywords: Adult; Aged; Cholinergic antagonists; Health-related quality of life; Multiple myeloma.

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