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. 1986 Apr;18(1-2):210-3.
doi: 10.1007/BF01988023.

Gastrointestinal histamine after gastric irradiation in the mouse

W K Man, A Michalowski, S K Li, J Barr, J Burgin

Gastrointestinal histamine after gastric irradiation in the mouse

W K Man et al. Agents Actions. 1986 Apr.

Abstract

A single dose of 9 or 15 Gy of X-rays was given to the stomach of mice. Gastric histamine formation capacity (HFC) rose in a dose-related fashion during days 4 to 11 after irradiation. This rise coincided with a dose-dependent fall in gastric mural histamine concentration. 15 Gy X-rays also resulted in a transient loss of body weight (days 4-8 after irradiation). These results suggest that irradiation of the stomach mobilizes gastric histamine and that gastric histamine stores may be radiosensitive.

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