Multicenter Study

. 2023 Nov 24;17(11):1791-1799.

doi: 10.1093/ecco-jcc/jjad097.

Autoimmune Pancreatitis in Patients with Inflammatory Bowel Disease: A Real-World Multicentre Collaborative ECCO CONFER Study

Piotr Eder¹, Bram Verstock², Emma Culver³, Gabriele Dragoni⁴, Lea Isabell Kredel⁵, Joanna Wypych⁶, Ana Garcia Garcia de Paredes⁷, Magdalena Kaniewska⁸, Haim Leibovitzh⁹, Triana Lobaton¹⁰, Marie Truyens¹⁰, Grzegorz Oracz¹¹, Davide Giuseppe Ribaldone¹², Teresa Starzyńska¹³, Abdenor Badaoui¹⁴, Jean-Francois Rahier¹⁴, Cristina Bezzio¹⁵, Peter Bossuyt¹⁶, Katherine Falloon¹⁷, Daniela Pugliese¹⁸, Catherine Frakes Vozzo¹⁷, Tine Jess¹⁹, Lone Larsen²⁰, Søren Schou Olesen²¹, Partha Pal²², María Chaparro²³, Dikla Dror²⁴, Pierre Ellul²⁵, Iga Gromny²⁶, Maria Janiak²⁷, Katarzyna Maciejewska⁸, Noam Peleg²⁸, Ariella Bar-Gil Shitrit²⁹, Łukasz Szwed³⁰, Renata Talar-Wojnarowska³¹, Yifat Snir³², Roni Weisshof³³, Eran Zittan³⁴, Izabela Miechowicz³⁵, Idan Goren³⁶

Affiliations

¹ Department of Gastroenterology, Dietetics, and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.
² Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
³ Translational Gastroenterology Unit, John Radcliffe Hospital and Oxford, NIHR BRC, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
⁴ Department of Gastroenterology, Careggi University Hospital, Florence, Italy.
⁵ Division of Gastroenterology, Infectiology and Rheumatology, Medical Department, Charité-Universitätsmedizin, Berlin, Germany.
⁶ Department of Gastroenterology, Surgery and Nutrition, Copernicus Hospital, Gdansk, Poland.
⁷ Gastroenterology and Hepatology Department. Hospital Universitario Ramon y Cajal. Universidad de Alcala, IRYCIS, Madrid, Spain.
⁸ Department of Gastroenterology with IBD Subdivision, National Medical Institute of Ministry of Inferior and Administration, Warsaw, Poland.
⁹ Zane Cohen Centre for Digestive Diseases, Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
¹⁰ Department of Internal Medicine and Pediatrics, Department of Gastroenterology, Ghent University, Ghent, Belgium.
¹¹ Department of Gastroenterology, Hepatology, Feeding Disorder and Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland; Pediatric Gastroenterology Faculty, Centre of Postgraduate Medical Education, Warsaw, Poland.
¹² Department of Medical Sciences, University of Turin, Turin, Italy.
¹³ Department of Gastroenterology, Pomeranian Medical University in Szczecin, Szczecin, Poland.
¹⁴ Department of Gastroenterology, Université Catholique de Louvain, Yvoir, Belgium.
¹⁵ Gastroenterology Unit, Rho Hospital, Rho (MI), ASST Rhodense, Garbagnate Milanese, Italy.
¹⁶ Imelda GI Clinical Research Center, Imelda General Hospital, Bonheiden, Belgium.
¹⁷ Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
¹⁸ CEMAD, IBD UNIT, Unità Operativa Complessa di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy.
¹⁹ Center for Molecular Prediction of Inflammatory Bowel Disease, Department of Clinical Medicine, Aalborg University, Copenhagen, Denmark.
²⁰ Department of Gastroenterology and Hepatology, Aalborg University Hospital, Center for Molecular Prediction of Inflammatory Bowel Disease - PREDICT, Department of Clinical Medicine, The Faculty of Medicine, Aalborg University, Aalborg, Denmark.
²¹ Centre for Pancreatic Diseases and Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
²² Department of Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.
²³ Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.
²⁴ Department of Gastroenterology, Galilee Medical Center, Nahariyya, Israel.
²⁵ Division of Gastroenterology, Mater dei Hospital, Malta.
²⁶ Division of Dietetics, Department of Gastroenterology and Hepatology, Wroclaw Medical University, Wroclaw, Poland.
²⁷ Department of Gastroenterology and Hepatology, Medical University of Gdańsk, Gdańsk, Poland.
²⁸ The Division of Gastroenterology, Rabin Medical Center, Petach Tikva, Israel, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
²⁹ IBD MOM Unit, Digestive Diseases Institute, The Hebrew University of Jerusalem, Shaare Zedek Medical Center, Jerusalem, Israel.
³⁰ Private Gastroenterology Practice, Nowy Dwór Mazowiecki, Poland.
³¹ Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.
³² Gastroenterology Department, Clalit Health Services, Tel Aviv District, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
³³ Gastroenterology Institute at Rambam Health Care Campus in Haifa, Haifa, Israel.
³⁴ Ellen and Pinchas Mamber Institute of Gastroenterology and Liver Diseases, IBD Unit, Emek Medical Center, Afula, Israel.
³⁵ Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland.
³⁶ Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

PMID: 37283545
PMCID: PMC10673810
DOI: 10.1093/ecco-jcc/jjad097

Multicenter Study

Autoimmune Pancreatitis in Patients with Inflammatory Bowel Disease: A Real-World Multicentre Collaborative ECCO CONFER Study

Piotr Eder et al. J Crohns Colitis. 2023.

. 2023 Nov 24;17(11):1791-1799.

doi: 10.1093/ecco-jcc/jjad097.

Authors

Affiliations

¹ Department of Gastroenterology, Dietetics, and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.
² Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium; Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
³ Translational Gastroenterology Unit, John Radcliffe Hospital and Oxford, NIHR BRC, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
⁴ Department of Gastroenterology, Careggi University Hospital, Florence, Italy.
⁵ Division of Gastroenterology, Infectiology and Rheumatology, Medical Department, Charité-Universitätsmedizin, Berlin, Germany.
⁶ Department of Gastroenterology, Surgery and Nutrition, Copernicus Hospital, Gdansk, Poland.
⁷ Gastroenterology and Hepatology Department. Hospital Universitario Ramon y Cajal. Universidad de Alcala, IRYCIS, Madrid, Spain.
⁸ Department of Gastroenterology with IBD Subdivision, National Medical Institute of Ministry of Inferior and Administration, Warsaw, Poland.
⁹ Zane Cohen Centre for Digestive Diseases, Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
¹⁰ Department of Internal Medicine and Pediatrics, Department of Gastroenterology, Ghent University, Ghent, Belgium.
¹¹ Department of Gastroenterology, Hepatology, Feeding Disorder and Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland; Pediatric Gastroenterology Faculty, Centre of Postgraduate Medical Education, Warsaw, Poland.
¹² Department of Medical Sciences, University of Turin, Turin, Italy.
¹³ Department of Gastroenterology, Pomeranian Medical University in Szczecin, Szczecin, Poland.
¹⁴ Department of Gastroenterology, Université Catholique de Louvain, Yvoir, Belgium.
¹⁵ Gastroenterology Unit, Rho Hospital, Rho (MI), ASST Rhodense, Garbagnate Milanese, Italy.
¹⁶ Imelda GI Clinical Research Center, Imelda General Hospital, Bonheiden, Belgium.
¹⁷ Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
¹⁸ CEMAD, IBD UNIT, Unità Operativa Complessa di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy.
¹⁹ Center for Molecular Prediction of Inflammatory Bowel Disease, Department of Clinical Medicine, Aalborg University, Copenhagen, Denmark.
²⁰ Department of Gastroenterology and Hepatology, Aalborg University Hospital, Center for Molecular Prediction of Inflammatory Bowel Disease - PREDICT, Department of Clinical Medicine, The Faculty of Medicine, Aalborg University, Aalborg, Denmark.
²¹ Centre for Pancreatic Diseases and Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
²² Department of Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India.
²³ Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.
²⁴ Department of Gastroenterology, Galilee Medical Center, Nahariyya, Israel.
²⁵ Division of Gastroenterology, Mater dei Hospital, Malta.
²⁶ Division of Dietetics, Department of Gastroenterology and Hepatology, Wroclaw Medical University, Wroclaw, Poland.
²⁷ Department of Gastroenterology and Hepatology, Medical University of Gdańsk, Gdańsk, Poland.
²⁸ The Division of Gastroenterology, Rabin Medical Center, Petach Tikva, Israel, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
²⁹ IBD MOM Unit, Digestive Diseases Institute, The Hebrew University of Jerusalem, Shaare Zedek Medical Center, Jerusalem, Israel.
³⁰ Private Gastroenterology Practice, Nowy Dwór Mazowiecki, Poland.
³¹ Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.
³² Gastroenterology Department, Clalit Health Services, Tel Aviv District, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
³³ Gastroenterology Institute at Rambam Health Care Campus in Haifa, Haifa, Israel.
³⁴ Ellen and Pinchas Mamber Institute of Gastroenterology and Liver Diseases, IBD Unit, Emek Medical Center, Afula, Israel.
³⁵ Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland.
³⁶ Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

PMID: 37283545
PMCID: PMC10673810
DOI: 10.1093/ecco-jcc/jjad097

Erratum in

Correction to: Autoimmune Pancreatitis in Patients with Inflammatory Bowel Disease: A Real-World Multicentre Collaborative ECCO CONFER Study.
[No authors listed] [No authors listed] J Crohns Colitis. 2025 May 8;19(5):jjaf077. doi: 10.1093/ecco-jcc/jjaf077. J Crohns Colitis. 2025. PMID: 40387533 Free PMC article. No abstract available.

Abstract

Background: Autoimmune pancreatitis [AIP] is rarely associated with inflammatory bowel disease [IBD]. The long-term outcomes of AIP and IBD in patients with coexisting AIP-IBD and predictors of complicated AIP course have rarely been reported.

Methods: An ECCO COllaborative Network For Exceptionally Rare case reports project [ECCO-CONFER] collected cases of AIP diagnosed in patients with IBD. Complicated AIP was defined as a composite of endocrine and/or exocrine pancreatic insufficiency, and/or pancreatic cancer. We explored factors associated with complicated AIP in IBD.

Results: We included 96 patients [53% males, 79% ulcerative colitis, 72% type 2 AIP, age at AIP diagnosis 35 ± 16 years]. The majority of Crohn's disease [CD] cases [78%] had colonic/ileocolonic involvement. In 59%, IBD preceded AIP diagnosis, whereas 18% were diagnosed simultaneously. Advanced therapy to control IBD was used in 61% and 17% underwent IBD-related surgery. In total, 82% of patients were treated with steroids for AIP, the majority of whom [91%] responded to a single course of treatment. During a mean follow-up of 7 years, AIP complications occurred in 25/96 [26%] individuals. In a multivariate model, older age at AIP diagnosis was associated with a complicated AIP course (odds ratio [OR] = 1.05, p = 0.008), whereas family history of IBD [OR = 0.1, p = 0.03], and CD diagnosis [OR = 0.2, p = 0.04] decreased the risk of AIP complications. No IBD- or AIP-related deaths occurred.

Conclusions: In this large international cohort of patients with concomitant AIP-IBD, most patients have type 2 AIP and colonic IBD. AIP course is relatively benign and long-term outcomes are favourable, but one-quarter develop pancreatic complications. Age, familial history of IBD, and CD may predict uncomplicated AIP course.

Keywords: Autoimmune pancreatitis; inflammatory bowel disease; pancreatic insufficiency.

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Conflict of interest statement

PE: Received lecture fees, consultancy fees, or travel educational grants from Takeda, Janssen, Pfizer, and Bristol Myers Squibb. BW: Research support from AbbVie, Biora Therapeutics, Pfizer, Sossei Heptares, and Takeda. Speaker’s fees from Abbvie, Biogen, Bristol Myers Squibb, Celltrion, Chiesi, Falk, Ferring, Galapagos, Janssen, MSD, Pfizer, R-Biopharm, Takeda, Truvion, and Viatris. Consultancy fees from Abbvie, Alimentiv, Applied Strategic, Atheneum, Biora Therapeutics, Bristol Myers Squibb, Galapagos, Guidepont, Mylan, Inotrem, Ipsos, Janssen, Progenity, Sandoz, Sosei Heptares, Takeda, Tillots Pharma, and Viatris. EC: Consultancy fees from Zenus Biopharma, Horizon Therapeutics, Sanofi, Modern,a and Falk Pharma and is supported by the National Institute Health Research [NIHR] Oxford Biomedical Research Centre [BRC]. GD, LIK, JW, AGGP, MK, HL, MT, GO, DRG, TS, AB, JFR, DP, CFV, TJ, LL, SO, PP, IG, MJ, KM, NP, ABGS, ŁSz, RTW, YS, EZ, IM, DD, PEl: Declare no conflict of interest. TL: Grant support from Abbvie, Mylan, MSD, Mundipharma, Biogen, Janssen, Pfizer, and Takeda. Speaker’s fees from Ferring, MSD, Abbvie, Janssen, Amgen, Fresenius Kabi, and Takeda. Consultancy Fees: Janssen, Galapagos, Amgen, Bristol Myers Squibb, Fresenius Kab. CB: Received lecture fees and served as a consultant for Takeda, MSD, Ferring, Galapagos, and Janssen. PB: Financial support for research from Abbvie, Amgen, Celltrion, Mylan, Pfizer, and Takeda; advisory board fees from Abbvie, Arena pharmaceuticals, BMS, Celltrion, CIRC, Dr Falk, Galapagos, Janssen, Lilly, Pentax, PSI-CRO, Roche, Takeda, and Tetrameros; lecture fees from AbbVie, Celltrion, EPGS, Galapagos, Janssen, Lilly, Materia Prima, Pentax, Scope, and Takeda. KF: Received grant funding from the Crohn’s and Colitis Foundation. She serves on a GI Fellows Steering Committee for Janssen. MCh: Speaker’s consultancy, research or education funding from MSD, Abbvie, Hospira, Pfizer, Takeda, Janssen, Ferring, Shire Pharmaceuticals, Dr. Falk Pharma, Tillotts Pharma, Biogen, Gilead, and Lilly. RW: Consultancy fee from Takeda, Janssen, and Abbvie. IGo: Research travel grants from ECCO and IOIBD. Institutional research support from Gilead, Boehringer Ingelheim, Pfizer, and Abbvie.

Figures

**Figure 1.**
Receiver operator curve illustrating the ability of a proposed multivariate model to predict complicated autoimmune pancreatitis in a cohort of inflammatory bowel disease patients.

See this image and copyright information in PMC

References

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Autoimmune Pancreatitis in Patients with Inflammatory Bowel Disease: A Real-World Multicentre Collaborative ECCO CONFER Study

Affiliations

Autoimmune Pancreatitis in Patients with Inflammatory Bowel Disease: A Real-World Multicentre Collaborative ECCO CONFER Study

Authors

Affiliations

Erratum in

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous