SARS-CoV-2 Infection in Patients With Waldenström's Macroglobulinemia: A Multicenter International Cohort Study

Irene Defrancesco^{1

2}, Virginia Valeria Ferretti³, Pierre Morel⁴, Charalampia Kyriakou⁵, Efstathios Kastritis⁶, Ibrahim Tohidi-Esfahani⁷, Alessandra Tedeschi⁸, Christian Buske⁹, Ramón García-Sanz¹⁰, Josephine M I Vos¹¹, Veronica Peri¹², Gloria Margiotta Casaluci¹³, Angela Ferrari¹⁴, Francesco Piazza^{15

16}, Rimke Oostvogels¹⁷, Ester Lovato¹⁸, Lydia Montes⁴, Luc Matthieu Fornecker¹⁹, Alexander Grunenberg²⁰, Meletios Athanasios Dimopoulos⁶, Constantine S Tam^{21

22

23}, Shirley D'Sa⁵, Veronique Leblond²⁴, Judith Trotman^{7

25}, Francesco Passamonti²⁶, Luca Arcaini^{1

27}, Marzia Varettoni¹

Affiliations

¹ Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
² Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Italy.
³ UOS Clinical Epidemiology and Biostatistic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
⁴ Service d'Hematologie Clinique et Therapie Cellulaire, Centre Hospitalier Universitaire d'Amiens-Picardie, France.
⁵ Centre for Waldenström's Macroglobulinaemia and Related Conditions, University College London Hospitals National Health Service Foundation Trust, London, United Kingdom.
⁶ Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Greece.
⁷ Haematology Department, Concord Repatriation General Hospital, Sydney, NSW, Australia.
⁸ ASST Grande Ospedale Metropolitano Niguarda Hospital, Milan, Italy.
⁹ Institute of Experimental Cancer Research, Comprehensive Cancer Center Ulm, University Hospital of Ulm, Germany.
¹⁰ Hematology Department, University Hospital of Salamanca, Research Biomedical Institute of Salamanca (IBSAL), CIBERONC and Center for Cancer Research-IBMCC (University of Salamanca-CSIC), Spain.
¹¹ Department of Hematology, Amsterdam UMC, Location University of Amsterdam, Cancer Center Amsterdam and LYMMCARE (Lymphoma and Myeloma Center Amsterdam), the Netherlands.
¹² Hematology Division, "AOU Città della Salute e della Scienza di Torino," Italy.
¹³ Division of Hematology, Department of Translational Medicine, Hospital Maggiore della Carità, Novara, Italy.
¹⁴ Hematology Unit, Azienda USL-IRCCS Reggio Emilia, Italy.
¹⁵ Laboratory of Myeloma and Lymphoma Pathobiology, Veneto Institute of Molecular Medicine (VIMM) and Foundation for Advanced Biomedical Research (FABR), Padua, Italy.
¹⁶ Hematology Division, Azienda Ospedaliera Universitaria and Department of Medicine, University of Padua, Italy.
¹⁷ Hematology, UMC Utrecht Cancer Center, Utrecht, the Netherlands.
¹⁸ Department of Medicine, Hematology Unit, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
¹⁹ Service d'Hematologie, Institut de Cancerologie Strasbourg Europe, Strasbourg, France.
²⁰ Department of Internal Medicine III, University Hospital Ulm, Germany.
²¹ Peter MacCallum Cancer Centre and University of Melbourne, VIC, Australia.
²² Alfred Health and Monash University, Melbourne, VIC, Australia.
²³ Central Clinical School, Monash University, Melbourne, VIC, Australia.
²⁴ Département d'Hématologie Hôpital Pitié-Salpêtrière APHP, UPMC Université Paris, France.
²⁵ University of Sydney, Camperdown, NSW, Australia.
²⁶ Department of Hematology, University Hospital "Ospedale di Circolo e Fondazione Macchi - ASST SetteLaghi," University of Insubria, Varese, Italy.
²⁷ Department of Molecular Medicine, University of Pavia, Italy.

PMID: 37283569
PMCID: PMC10241499
DOI: 10.1097/HS9.0000000000000887

SARS-CoV-2 Infection in Patients With Waldenström's Macroglobulinemia: A Multicenter International Cohort Study

Irene Defrancesco et al. Hemasphere. 2023.

. 2023 Jun 2;7(6):e887.

doi: 10.1097/HS9.0000000000000887. eCollection 2023 Jun.

Authors

Affiliations

¹ Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
² Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Italy.
³ UOS Clinical Epidemiology and Biostatistic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
⁴ Service d'Hematologie Clinique et Therapie Cellulaire, Centre Hospitalier Universitaire d'Amiens-Picardie, France.
⁵ Centre for Waldenström's Macroglobulinaemia and Related Conditions, University College London Hospitals National Health Service Foundation Trust, London, United Kingdom.
⁶ Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Greece.
⁷ Haematology Department, Concord Repatriation General Hospital, Sydney, NSW, Australia.
⁸ ASST Grande Ospedale Metropolitano Niguarda Hospital, Milan, Italy.
⁹ Institute of Experimental Cancer Research, Comprehensive Cancer Center Ulm, University Hospital of Ulm, Germany.
¹⁰ Hematology Department, University Hospital of Salamanca, Research Biomedical Institute of Salamanca (IBSAL), CIBERONC and Center for Cancer Research-IBMCC (University of Salamanca-CSIC), Spain.
¹¹ Department of Hematology, Amsterdam UMC, Location University of Amsterdam, Cancer Center Amsterdam and LYMMCARE (Lymphoma and Myeloma Center Amsterdam), the Netherlands.
¹² Hematology Division, "AOU Città della Salute e della Scienza di Torino," Italy.
¹³ Division of Hematology, Department of Translational Medicine, Hospital Maggiore della Carità, Novara, Italy.
¹⁴ Hematology Unit, Azienda USL-IRCCS Reggio Emilia, Italy.
¹⁵ Laboratory of Myeloma and Lymphoma Pathobiology, Veneto Institute of Molecular Medicine (VIMM) and Foundation for Advanced Biomedical Research (FABR), Padua, Italy.
¹⁶ Hematology Division, Azienda Ospedaliera Universitaria and Department of Medicine, University of Padua, Italy.
¹⁷ Hematology, UMC Utrecht Cancer Center, Utrecht, the Netherlands.
¹⁸ Department of Medicine, Hematology Unit, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
¹⁹ Service d'Hematologie, Institut de Cancerologie Strasbourg Europe, Strasbourg, France.
²⁰ Department of Internal Medicine III, University Hospital Ulm, Germany.
²¹ Peter MacCallum Cancer Centre and University of Melbourne, VIC, Australia.
²² Alfred Health and Monash University, Melbourne, VIC, Australia.
²³ Central Clinical School, Monash University, Melbourne, VIC, Australia.
²⁴ Département d'Hématologie Hôpital Pitié-Salpêtrière APHP, UPMC Université Paris, France.
²⁵ University of Sydney, Camperdown, NSW, Australia.
²⁶ Department of Hematology, University Hospital "Ospedale di Circolo e Fondazione Macchi - ASST SetteLaghi," University of Insubria, Varese, Italy.
²⁷ Department of Molecular Medicine, University of Pavia, Italy.

PMID: 37283569
PMCID: PMC10241499
DOI: 10.1097/HS9.0000000000000887

No abstract available

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

**Figure 1.**
**OS at 100 d from SARS-CoV-2 infection in WM patients.** d = days; OS = overall survival; SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2; WM = Waldenström’s macroglobulinemia.

See this image and copyright information in PMC

References

1. Passamonti F, Cattaneo C, Arcaini L, et al. . Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study. Lancet Haematol. 2020;7:e737–e745. - PMC - PubMed
1. Pagano L, Salmanton-García J, Marchesi F, et al. . COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA). J Hematol Oncol. 2021;14:168. - PMC - PubMed
1. Merli M, Ferrarini I, Merli F, et al. . SARS-CoV-2 infection in patients with chronic lymphocytic leukemia: the Italian Hematology Alliance on COVID-19 cohort. Hematol Oncol. 2022;41:128–138. - PMC - PubMed
1. Visco C, Marcheselli L, Mina R, et al. . A prognostic model for patients with lymphoma and COVID-19: a multicentre cohort study. Blood Adv. 2022;6:327–338. - PMC - PubMed
1. Lamure S, Duléry R, Di Blasi R, et al. . Determinants of outcome in Covid-19 hospitalized patients with lymphoma: a retrospective multicentric cohort study. EClinicalMedicine. 2020;27:100549. - PMC - PubMed

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SARS-CoV-2 Infection in Patients With Waldenström's Macroglobulinemia: A Multicenter International Cohort Study

Affiliations

SARS-CoV-2 Infection in Patients With Waldenström's Macroglobulinemia: A Multicenter International Cohort Study

Authors

Affiliations

Conflict of interest statement

Figures

References

LinkOut - more resources

Full Text Sources

Miscellaneous