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. 2023 Jun 1;13(6):4007-4014.
doi: 10.21037/qims-22-1018. Epub 2023 Apr 4.

Synchronous carotid body and anterior mediastinal paraganglioma revealed by 18F-fluorodeoxyglucose and 68Ga-DOTA(0)-Tyr(3)-octreotate positron emission tomography-computed tomography

Hangyu Xie #  1 , Hua Lin #  1 , Lin Li #  1 , Wenjie Zhang #  1
Affiliations

Synchronous carotid body and anterior mediastinal paraganglioma revealed by 18F-fluorodeoxyglucose and 68Ga-DOTA(0)-Tyr(3)-octreotate positron emission tomography-computed tomography

Hangyu Xie et al. Quant Imaging Med Surg. .
No abstract available

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://qims.amegroups.com/article/view/10.21037/qims-22-1018/coif). The authors report that this research was supported by the 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (No. ZYGD18016), and the Sichuan Science and Technology Program (No. 2022YFH0047). The authors have no other conflicts of interest to declare.

Figures

Figure 1
Figure 1
A 3D reconstruction of vessels and the contrast-enhanced CT finding. (A) A 3D reconstruction of the cervical vessels showed a mass enclosing the right distal CCA, the carotid bifurcation, ICA, and ECA. (B) Contrast-enhanced CT showed a highly vascularized lesion on the right side of the upper neck. 3D, 3-dimensional; CT, computed tomography; CCA, common carotid artery; ICA, the proximal internal carotid artery; ECA, the external carotid artery.
Figure 2
Figure 2
18F-FDG and 68Ga-DOTATATE PET-CT imaging of the right upper neck and the anterior mediastinum lesions. (A,B) MIP. The short black arrow indicates the neck region, and the long black arrow indicates the thoracic region). (C,D: short blue arrow) Axial CT of the neck and chest. (E,F: long blue arrow) FDG PET-CT fusion images. (G,H: orange arrow) PET imaging. (I,J: short white arrow) Axial CT of the chest. (K,L: long white arrow) DOTATATE PET-CT fusion imaging. (M,N: red arrow) PET imaging revealed a soft tissue mass in the right neck and anterior mediastinum with increased 18F-FDG and 68Ga-DOTATATE uptake. 18F-FDG, 18F-fluorodeoxyglucose; 68Ga-DOTATATE, 68Ga-DOTA(0)-Tyr(3)-octreotate; PET-CT, positron emission tomography-computed tomography; MIP, maximum intensity projection.
Figure 3
Figure 3
The pathology of the tumor showed carotid body paraganglioma. HE staining showed that the tumor was composed of nests of cells arranged in a classic Zellballen pattern with abundant blood sinuses between cell nests (magnification ×200). No immunohistochemical staining was performed for this lesion. HE, hematoxylin and eosin.
Figure 4
Figure 4
The pathology of the tumor showing anterior mediastinal paraganglioma. (A) HE staining showed that the tumor was composed of nests of cells arranged in a classic Zellballen pattern with abundant blood sinuses between cell nests (magnification ×200). (B-D) Immunohistochemical staining showed CgA, S-100, and Syn positivity (+) in tumor cells (magnification ×100). HE, hematoxylin and eosin; CgA, chromogranin A; Syn, synaptophysin.
See this image and copyright information in PMC

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