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Review
. 2023 Oct 1;23(5):390-396.
doi: 10.1097/ACI.0000000000000915. Epub 2023 Jun 6.

Diagnostic criteria of chronic conjunctivitis: atopic keratoconjunctivitis and vernal keratoconjunctivitis

Andrea Leonardi  1 , Giuseppe Righetti, Giulia Giovannini, Vittorio De Marchi, Matteo Occhiuto
Affiliations
Review

Diagnostic criteria of chronic conjunctivitis: atopic keratoconjunctivitis and vernal keratoconjunctivitis

Andrea Leonardi et al. Curr Opin Allergy Clin Immunol. .

Abstract

Purpose of review: Chronic ocular allergies, vernal (VKC) and atopic keratoconjunctivitis (AKC) are relatively rare conditions that require definite diagnostic criteria to the most appropriate therapeutical approach.

Recent findings: The diagnosis of both VKC and AKC is generally based on clinical history, signs and symptoms, and the results of allergic tests, which allow to identify the different diseases phenotypes. However, other subtypes of the two diseases and/or overlaps may occur making the diagnosis non always so clear, such as VKC and AKC overlaps or adult-like VKC disease. Each of these phenotypes may be sustained by different mechanisms which are still not well defined but not only related to a type 2 inflammation. The further challenges will be to correlate clinical or molecular biomarkers to a single subtype or disease severity.

Summary: Definite criteria of chronic allergies will further guide to more specific therapeutical approaches.

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References

    1. Leonardi A, Bogacka E, Fauquert JL, et al. Ocular allergy: recognizing and diagnosing hypersensitivity disorders of the ocular surface. Allergy 2012; 67:1327–1337.
    1. Bonini S, Leonardi A. The multifaceted aspects of ocular allergies: phenotypes and endotypes. Ocul Surf 2022; 26:174–183.
    1. Agache I, Akdis CA. Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases. J Clin Invest 2019; 129:1493–1503.
    1. Leonardi A, Daull P, Garrigue JS, et al. Conjunctival transcriptome analysis reveals the overexpression of multiple pattern recognition receptors in vernal keratoconjunctivitis. Ocul Surf 2021; 19:241–248.
    1. Matsuda A, Asada Y, Suita N, et al. Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing. J Allergy Clin Immunol 2019; 143:1610–1614. e6.