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Review
. 2023 Jun:7:e2200715.
doi: 10.1200/PO.22.00715.

Comprehensive Review on the Clinical Impact of Next-Generation Sequencing Tests for the Management of Advanced Cancer

Sarah N Gibbs  1 , Desi Peneva  1 , Gebra Cuyun Carter  2 , Melanie R Palomares  2 , Snehal Thakkar  2 , David W Hall  2 , Hannah Dalglish  1 , Cynthia Campos  1 , Irina Yermilov  1
Affiliations
Review

Comprehensive Review on the Clinical Impact of Next-Generation Sequencing Tests for the Management of Advanced Cancer

Sarah N Gibbs et al. JCO Precis Oncol. 2023 Jun.

Abstract

Purpose: This review summarizes the published evidence on the clinical impact of using next-generation sequencing (NGS) tests to guide management of patients with cancer in the United States.

Methods: We performed a comprehensive literature review to identify recent English language publications that presented progression-free survival (PFS) and overall survival (OS) of patients with advanced cancer receiving NGS testing.

Results: Among 6,475 publications identified, 31 evaluated PFS and OS among subgroups of patients who received NGS-informed cancer management. PFS and OS were significantly longer among patients who were matched to targeted treatment in 11 and 16 publications across tumor types, respectively.

Conclusion: Our review indicates that NGS-informed treatment can have an impact on survival across tumor types.

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Conflict of interest statement

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated unless otherwise noted. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/po/author-center.

Open Payments is a public database containing information reported by companies about payments made to US-licensed physicians (Open Payments).

Figures

FIG 1.
FIG 1.
Flow diagram (journal publications). a Only one reason for exclusion was required to exclude a study during the screening process although more than one reason could be selected. Therefore, reasons for exclusion do not sum to the number excluded. b Refs. , , -. NGS, next-generation sequencing; OS, overall survival; PFS, progression-free survival.
FIG 2.
FIG 2.
Flow diagram (conference abstracts). a Only one reason for exclusion was required to exclude a study during the screening process although more than one reason could be selected. Therefore, reasons for exclusion do not sum to the number excluded. b Ref. . NGS, next-generation sequencing; OS, overall survival; PFS, progression-free survival.
See this image and copyright information in PMC

References

    1. Bewicke-Copley F, Arjun Kumar E, Palladino G, et al. Applications and analysis of targeted genomic sequencing in cancer studies. Comput Struct Biotechnol J. 2019;17:1348–1359. - PMC - PubMed
    1. Robson ME, Bradbury AR, Arun B, et al. American Society of Clinical Oncology policy statement update: Genetic and genomic testing for cancer susceptibility. J Clin Oncol. 2015;33:3660–3667. - PubMed
    1. Nagahashi M, Shimada Y, Ichikawa H, et al. Next generation sequencing-based gene panel tests for the management of solid tumors. Cancer Sci. 2019;110:6–15. - PMC - PubMed
    1. Kris MG, Johnson BE, Berry LD, et al. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA. 2014;311:1998–2006. - PMC - PubMed
    1. Del Vecchio F, Mastroiaco V, Di Marco A, et al. Next-generation sequencing: Recent applications to the analysis of colorectal cancer. J Transl Med. 2017;15:246. - PMC - PubMed

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