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. 2023 Aug 8;7(15):4182-4185.
doi: 10.1182/bloodadvances.2023010368.

Absolute neutrophil count nadir in healthy pediatric patients with the Duffy-null phenotype

Lauren E Merz  1 , Shih-Hon Li  2 , Gina Ney  3 , Thomas F Michniacki  3 , Mark C Hannibal  4 , Kelly J Walkovich  3
Affiliations

Absolute neutrophil count nadir in healthy pediatric patients with the Duffy-null phenotype

Lauren E Merz et al. Blood Adv. .
No abstract available

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Conflict of interest statement

Conflict-of-interest disclosure: S.-H.L. is a consultant for Molecular Innovations, Novi, and MI; has a chair in the education committee for Michigan Society of Pathologists; is a member of CP Certlink and Chemical Pathology Test Development; and serves in advisory committees for the American Board of Pathology. T.F.M. consults for X4 Pharmaceuticals. K.J.W. is on advisory boards for Sobi, Pharming Group, X4 Pharmaceuticals, Agios; research funding from X4 Pharmaceuticals (Local PI), Pharming Group (Project PI); and serves in professional committees as NICER Consortium Executive Chair, with sponsored testing program with Blueprint Genetics. The remaining authors declare no competing financial interests.

The current affiliation of G.N. is Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, Bethesda, MD.

Figures

Figure 1.
Figure 1.
All healthy Fy(a-b-) ANC values and control ANC values. ANC values of healthy children with the Fy(a-b-) phenotype (red triangles; n = 251) compared with healthy controls (blue circles; n = 134) based on age. The shaded area represents the ANC institutional reference range based on age.
Figure 2.
Figure 2.
ANC nadir values of healthy children with the Fy(a-b-) phenotype. Dotted lines indicate the degree of neutropenia: mild- ANC, from 1000 to 1500 cells per μL; moderate- ANC, from 500 to 999 cells per μL; and severe- ANC, <500 per μL. Children younger than 5 years had an ANC as low as 100 cells per μL. Children older than 5 years had an ANC as low as 400 cells per μL but rarely had values <500 cells per μL.
See this image and copyright information in PMC

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