The cellular supply-side economics for phospholipids
- PMID: 37285806
- DOI: 10.1016/j.cmet.2023.05.004
The cellular supply-side economics for phospholipids
Abstract
Choline is an essential nutrient, but how cells acquire it was not known. Two studies by Kenny et al. and Tsuchiya et al. identified the plasma membrane proteins FLVCR1 and FLVCR2 to be the bona fide choline transporters mediating choline uptake for de novo synthesis of phospholipids in all cells.
Copyright © 2023 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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Organelle-selective click labeling coupled with flow cytometry allows pooled CRISPR screening of genes involved in phosphatidylcholine metabolism.Cell Metab. 2023 Jun 6;35(6):1072-1083.e9. doi: 10.1016/j.cmet.2023.02.014. Epub 2023 Mar 13. Cell Metab. 2023. PMID: 36917984
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Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals.Cell Metab. 2023 Jun 6;35(6):1057-1071.e12. doi: 10.1016/j.cmet.2023.04.003. Epub 2023 Apr 25. Cell Metab. 2023. PMID: 37100056 Free PMC article.
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