Gut microbiota bridges dietary nutrients and host immunity

Lijuan Fan^#¹, Yaoyao Xia^#¹, Youxia Wang^#¹, Dandan Han^#², Yanli Liu^#³, Jiahuan Li^#⁴, Jie Fu^#⁵, Leli Wang^#⁶, Zhending Gan¹, Bingnan Liu¹, Jian Fu¹, Congrui Zhu¹, Zhenhua Wu², Jinbiao Zhao², Hui Han⁷, Hao Wu⁴, Yiwen He^{6

8}, Yulong Tang⁶, Qingzhuo Zhang¹, Yibin Wang³, Fan Zhang³, Xin Zong⁹, Jie Yin¹⁰, Xihong Zhou¹¹, Xiaojun Yang¹², Junjun Wang¹³, Yulong Yin^{14

15}, Wenkai Ren¹⁶

Affiliations

¹ Guangdong Laboratory of Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
² State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
³ College of Animal Science and Technology, Northwest A&F University, Xi'an, 712100, China.
⁴ State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
⁵ College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.
⁶ Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China.
⁷ Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
⁸ Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.
⁹ College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China. zongxin@zju.edu.cn.
¹⁰ College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China. yinjie@hunau.edu.cn.
¹¹ Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China. xhzhou@isa.ac.cn.
¹² College of Animal Science and Technology, Northwest A&F University, Xi'an, 712100, China. yangxj@nwsuaf.edu.cn.
¹³ State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China. wangjj@cau.edu.cn.
¹⁴ Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China. yinyulong@isa.ac.cn.
¹⁵ College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China. yinyulong@isa.ac.cn.
¹⁶ Guangdong Laboratory of Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China. renwenkai19@scau.edu.cn.

^# Contributed equally.

PMID: 37286860
PMCID: PMC10247344
DOI: 10.1007/s11427-023-2346-1

Gut microbiota bridges dietary nutrients and host immunity

Lijuan Fan et al. Sci China Life Sci. 2023 Nov.

. 2023 Nov;66(11):2466-2514.

doi: 10.1007/s11427-023-2346-1. Epub 2023 Jun 5.

Authors

Affiliations

¹ Guangdong Laboratory of Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
² State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
³ College of Animal Science and Technology, Northwest A&F University, Xi'an, 712100, China.
⁴ State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
⁵ College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.
⁶ Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China.
⁷ Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
⁸ Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.
⁹ College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China. zongxin@zju.edu.cn.
¹⁰ College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China. yinjie@hunau.edu.cn.
¹¹ Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China. xhzhou@isa.ac.cn.
¹² College of Animal Science and Technology, Northwest A&F University, Xi'an, 712100, China. yangxj@nwsuaf.edu.cn.
¹³ State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China. wangjj@cau.edu.cn.
¹⁴ Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, China. yinyulong@isa.ac.cn.
¹⁵ College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China. yinyulong@isa.ac.cn.
¹⁶ Guangdong Laboratory of Lingnan Modern Agriculture, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China. renwenkai19@scau.edu.cn.

^# Contributed equally.

PMID: 37286860
PMCID: PMC10247344
DOI: 10.1007/s11427-023-2346-1

Abstract

Dietary nutrients and the gut microbiota are increasingly recognized to cross-regulate and entrain each other, and thus affect host health and immune-mediated diseases. Here, we systematically review the current understanding linking dietary nutrients to gut microbiota-host immune interactions, emphasizing how this axis might influence host immunity in health and diseases. Of relevance, we highlight that the implications of gut microbiota-targeted dietary intervention could be harnessed in orchestrating a spectrum of immune-associated diseases.

Keywords: amino acid; carbohydrate; gut microbiota; immunity; lipid; trace element; vitamin.

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References

1. Abdalkareem Jasim S, Jade Catalan Opulencia M, Alexis Ramírez-Coronel A, Kamal Abdelbasset W, Hasan Abed M, Markov A, Raheem Lateef Al-Awsi G, Azamatovich Shamsiev J, Thaeer Hammid A, Nader Shalaby M, et al. The emerging role of microbiota-derived short-chain fatty acids in immunometabolism. Int Immunopharmacol. 2022;110:108983. doi: 10.1016/j.intimp.2022.108983. - DOI - PubMed
1. Abe RAM, Masroor A, Khorochkov A, Prieto J, Singh KB, Nnadozie MC, Abdal M, Shrestha N, Mohammed L. The role of vitamins in non-alcoholic fatty liver disease: a systematic review. Cureus. 2021;13:e16855. - PMC - PubMed
1. Abidin MZ, Saravanan T, Zhang J, Tepper PG, Strauss E, Poelarends GJ. Modular enzymatic cascade synthesis of vitamin B5 and its derivatives. Chem Eur J. 2018;24:17434–17438. doi: 10.1002/chem.201804151. - DOI - PMC - PubMed
1. Akiba, Y., Maruta, K., Takajo, T., Narimatsu, K., Said, H., Kato, I., Kuwahara, A., and Kaunitz, J.D. (2020). Lipopolysaccharides transport during fat absorption in rodent small intestine. Am J Physiol Gastrointest Liver Physiol 318, G1070–G1087. - PMC - PubMed
1. Akkerman R, Faas MM, de Vos P. Non-digestible carbohydrates in infant formula as substitution for human milk oligosaccharide functions: effects on microbiota and gut maturation. Crit Rev Food Sci Nutr. 2019;59:1486–1497. doi: 10.1080/10408398.2017.1414030. - DOI - PubMed

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Gut microbiota bridges dietary nutrients and host immunity

Affiliations

Gut microbiota bridges dietary nutrients and host immunity

Authors

Affiliations

Abstract

References

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