Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Dec;26(12):2572-2575.
doi: 10.1111/1756-185X.14755. Epub 2023 Jun 7.

Anti-nuclear matrix protein 2 antibody-positive dermatomyositis with gastrointestinal ulcers: A case report

Naohiro Uchio  1 , Shogo Komaki  1 , Takashi Sudo  1 , Yusuke Matsumoto  1 , Akihito Hao  1 , Kentaro Kojima  2 , Nobuo Toda  2 , Asuka Kitamura  3 , Meiko Hashimoto Maeda  3 , Akatsuki Kubota  3 , Hideyuki Matsumoto  1
Affiliations
Case Reports

Anti-nuclear matrix protein 2 antibody-positive dermatomyositis with gastrointestinal ulcers: A case report

Naohiro Uchio et al. Int J Rheum Dis. 2023 Dec.

Abstract

Gastrointestinal manifestations are a very rare complication of dermatomyositis (DM) and are much less frequent in adult cases than in juvenile cases. Only a few previous papers have reported adult patients who had DM with anti-nuclear matrix protein 2 (anti-NXP2) antibodies and who developed gastrointestinal ulcers. Herein, we report a similar case of a 50-year-old man who had DM with anti-NXP2 antibodies followed by relapsing multiple gastrointestinal ulcers. Even after the administration of prednisolone, his muscle weakness and myalgia deteriorated and gastrointestinal ulcers relapsed. In contrast, intravenous immunoglobulin and azathioprine improved his muscle weakness and gastrointestinal ulcers. Based on the parallel disease activity of the muscular and gastrointestinal symptoms, we considered that his gastrointestinal ulcers were a complication of DM with anti-NXP2 antibodies. We also propose that early intensive immunosuppressive therapy would be required for the muscular and gastrointestinal symptoms in DM with anti-NXP2 antibodies.

Keywords: anti-NXP2 antibody; dermatomyositis; extramuscular lesions; gastrointestinal ulcers.

PubMed Disclaimer

References

REFERENCES

    1. Robinson AB, Reed AM. Clinical features, pathogenesis and treatment of juvenile and adult dermatomyositis. Nat Rev Rheumatol. 2011;7(11):664-675.
    1. Matas-Garcia A, Milisenda JC, Espinosa G, et al. Gastrointestinal involvement in dermatomyositis. Diagnostics. 2022;12(5):1200.
    1. Trefond L, Smets P, Beltzung F, et al. Digestive vasculitis: a rare but severe complication of NXP2 dermatomyositis. Rheumatology. 2021;60:E165-E166.
    1. Valenzuela A, Rieger KE, Blish CA, Chung L, Fiorentino D. Gastrointestinal perforation in a patient with antinuclear matrix protein 2 antibody-positive dermatomyositis. Arthritis Care Res (Hoboken). 2022;74(9):1409-1415.
    1. Mammen AL, Allenbach Y, Stenzel W, et al. 239th ENMC international workshop: classification of dermatomyositis, Amsterdam, The Netherlands, 14-16 December 2018. Neuromuscul Disord. 2020;30(1):70-92.

Publication types

LinkOut - more resources