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Review
. 2023 May 27:19:100372.
doi: 10.1016/j.lrr.2023.100372. eCollection 2023.

Gray zone lymphoma: A case report and comprehensive review of literature

Dariusz Uczkowski  1 , Hamza Ashraf  1 , Mohamad Cherry  2 , Nikolay Dimov  2
Affiliations
Review

Gray zone lymphoma: A case report and comprehensive review of literature

Dariusz Uczkowski et al. Leuk Res Rep. .

Abstract

Gray zone lymphoma is a very rare liquid malignancy that possesses intersecting features between primary mediastinal B-cell lymphoma and classic Hodgkin Lymphoma. In the case presented and accompanying literature review, we will discuss a patient with a chief complaint of shortness of breath and was found to have a mediastinal mass with biopsy consistent with mediastinal gray zone lymphoma. Herein, we explore the historical and recently updated diagnostic criteria of gray zone lymphoma from 2022 as well as the pathophysiology as it pertains to gene expression, while also reviewing the histological findings, epidemiology and treatment modalities.

Keywords: Chemotherapy; Grey; Hodgkin; Immunotherapy; Mediastinum.

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Conflict of interest statement

None.

Figures

Fig 1
Fig. 1
A-C. 1A: Sagittal view of CT angiogram of the chest revealing mediastinal mass. 1B: PET scan after 2 cycles of dose adjusted EPOCH. Notably with significant debulking of mediastinal mass. 1C: PET scan after 3 cycles of dose adjusted EPOCH. Complete metabolic response with a Deauville score of 2.
Fig 2
Fig. 2
A-B. 2A-strong CD15 expression 2B-diffuse and strong expression of CD30 image obtained from Morristown Medical Center Pathology Department with consent obtained from patient.
Fig 3
Fig. 3
B-cell lineage confirmed by PAX5 expression; CD20 and CD79a stains negative. Image obtained from Morristown Medical Center Pathology Department with consent obtained from patient.
Fig 4
Fig. 4
A-B. 4A- Diffuse proliferation of large neoplastic cells with variably fibrotic and finely vascular background and lack of pleomorphic inflammatory infiltrate. 4B- The neoplastic cells are large, with oval to lobulated nuclear contours, vesicular chromatin and conspicuous to prominent nucleoli. Image obtained from Morristown Medical Center Pathology Department with consent obtained from patient.
See this image and copyright information in PMC

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