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. 2023 May 23:14:1097991.
doi: 10.3389/fendo.2023.1097991. eCollection 2023.

First trimester sCD40L levels associated with adverse neonatal outcomes in euthyroid pregnant women with positive TPOAb

Xinxin Chen  1 , Qingyao Wang  1 , Huanhuan Zang  1 , Xiangguo Cong  1 , Qiong Shen  1 , Lei Chen  1
Affiliations

First trimester sCD40L levels associated with adverse neonatal outcomes in euthyroid pregnant women with positive TPOAb

Xinxin Chen et al. Front Endocrinol (Lausanne). .

Abstract

Backgrounds: It remained unclear whether isolated positive thyroid peroxidative antibodies (TPOAb) were associated with adverse maternal and neonatal outcomes. The purpose of this study was to observe adverse neonatal outcomes among euthyroid pregnant women with positive TPOAb and to investigate the underlying risk factors.

Methods: Euthyroid pregnant women with TPOAb positivity were enrolled and followed up in our study. Adverse neonatal outcomes such as preterm birth, low birth weight, and fetal macrosomia were observed. Clinical data in the first trimester were collected and compared between groups with or without adverse neonatal outcomes. Maternal serum soluble CD40 ligand (sCD40L) was also measured at the same time.

Results: A total of 176 euthyroid pregnant women with TPOAb positivity were finally enrolled and analyzed in our study. Thirty-nine (22.16%) euthyroid women with TPOAb positivity were found to have adverse neonatal outcomes. Thirteen participants received assisted reproductive technology (ART) in our study, and seven participants were in the adverse neonatal outcome group. Preterm birth, low birth weight, and fetal macrosomia were the most common comorbidities. The proportion of receiving ART and the levels of sCD40L and platelet were significantly higher in the adverse neonatal outcome group (all P < 0.05). Multivariate regression analysis showed that sCD40L and receiving ART were the independent risk factors for adverse neonatal outcomes. The odds ratio values of sCD40L higher than 5.625 ng/ml were 2.386 [95% confidence interval (CI) = 1.017 to 5.595; P = 0.046] for overall adverse neonatal outcome, 3.900 (95% CI = 1.194 to 12.738; P = 0.024) for preterm birth, and 3.149 (95% CI = 0.982 to 10.101; P = 0.054) for low birth weight.

Conclusions: Approximately one of the four euthyroid women with TPOAb positivity might have adverse neonatal outcomes. Measurement of sCD40L in first trimester might have a predictive value for adverse neonatal outcomes in euthyroid pregnant women with positive TPOAb.

Keywords: adverse neonatal outcomes; platelet; pregnancy; sCD40L; thyroid peroxidase antibody.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of study.
Figure 2
Figure 2
Comparison of sCD40L and platelet among groups with or without adverse neonatal outcomes. According to types of adverse neonatal outcomes, participants were divided into groups with normal neonatal outcome, overall adverse outcomes, preterm birth, low birth weight, and fetal macrosomia. sCD40L (A) and platelet (B) were compared among groups using one-way ANOVA test. *P < 0.05.
Figure 3
Figure 3
ROC curve for sCD40L and platelet levels in early pregnancy in predicting adverse neonatal outcomes.
Figure 4
Figure 4
Forest plot of multivariate logistic regression analysis of risk factors for adverse neonatal outcomes in euthyroid pregnant women with positive TPOAb.
Figure 5
Figure 5
Forest plot of multivariate logistic regression analysis of risk factors for preterm birth in euthyroid pregnant women with positive TPOAb.
Figure 6
Figure 6
Forest plot of multivariate logistic regression analysis of risk factors for low birth weight in euthyroid pregnant women with positive TPOAb.
See this image and copyright information in PMC

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