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Case Reports
. 2023 May 25:47:101207.
doi: 10.1016/j.gore.2023.101207. eCollection 2023 Jun.

Cracking the case: The diagnosis and treatment of a complex high-grade endometrial carcinoma with hepatoid, endometrioid, serous features and somatically derived yolk sac tumor component in a 50 year old female

Cailin O'Connell  1 , Sylvia Jang  2 , Paloma Monroig-Bosque  2 , Anne Alaniz  3
Affiliations
Case Reports

Cracking the case: The diagnosis and treatment of a complex high-grade endometrial carcinoma with hepatoid, endometrioid, serous features and somatically derived yolk sac tumor component in a 50 year old female

Cailin O'Connell et al. Gynecol Oncol Rep. .

Abstract

•Alpha-fetoprotein secreting tumors in gynecologic cancers have a broad differential.•Surgical pathology may provide a more comprehensive picture of tumor heterogeneity than initial biopsy.•Yolk Sac Tumor components intermixed with carcinoma points towards a somatic derivative rather than a collision tumor.•Alpha-fetoprotein can be trended over time to gauge response to treatment of cancers that produce the protein.

Keywords: Alpha-fetoprotein; Endometrial carcinoma; Endometroid; Hepatoid; Uterine cancer; Yolk sac tumor.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Pelvic MRI demonstrating umbilicated lower uterine segment mass at presentation (Axial T2 Haste).
Fig. 2
Fig. 2
Initial biopsy results demonstrating staining of (A) CK7, (B) P53, (C) ER, (D) PR, (E) AFP, (F) Arginase, (G) Glypican 3, (H) HepPar1.
Fig. 3
Fig. 3
Trend of AFP level over time from presentation. Blue shading represents the time the patient was on four cycles of paclitaxel/carboplatin and recovery (Days 31–119). Orange shading represents the time the patient underwent surgical cytoreduction and recovery (Days 119–167). Surgical pathology revealed primary YST component. Subsequently, gray shading represents the time the patient underwent four cycles of BEP (Days 167–226). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
See this image and copyright information in PMC

References

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