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. 2023 Sep;54(3):1761-1767.
doi: 10.1007/s42770-023-01019-w. Epub 2023 Jun 8.

Paracoccidioidomycosis cases by Paracoccidioides lutzii in southeastern Brazil

Wdson Luis Lima Kruschewsky  1 , Suzana Alves Patricio  2 , Isabela Cruz Bahiense  3 , Simone Bravim Maifrede  4 , Ana Paula Pôssa  5 , Zoilo Pires de Camargo  5 , Anderson Messias Rodrigues  5 , Paulo Mendes Peçanha  1   6 , Aloísio Falqueto  1   7 , Tânia Regina Grão-Velloso  8 , Sarah Santos Gonçalves  3   4
Affiliations

Paracoccidioidomycosis cases by Paracoccidioides lutzii in southeastern Brazil

Wdson Luis Lima Kruschewsky et al. Braz J Microbiol. 2023 Sep.

Erratum in

Abstract

Background and objective: Paracoccidioidomycosis (PCM) is a systemic fungal disease caused by the thermodimorphic fungi Paracoccidioides spp. Their distribution is highly variable. Paracoccidioides lutzii is predominantly found in North and Middle-West Brazil and Ecuador. This study evaluated the clinicopathological characteristics of 10 patients diagnosed with PCM caused by P. lutzii in a reference center located in southeastern Brazil.

Design: Double immunodiffusion assay (DID) was used to investigate 35 patients' sera with negative serology for P. brasiliensis against a P. lutzii CFA (cell-free antigen).

Results: Out of the 35 retested patients, 10 (28.6%) were positive for P. lutzii CFA. Four patients did not report any displacement to P. lutzii endemic areas. Our results reinforce the importance of using different antigens when testing patients with clinical manifestations of PCM and negative serological tests for P. brasiliensis, primarily in cases of the report of displacement to or former residence in P. lutzii endemic regions.

Conclusions: The availability of tests for different Paracoccidioides species antigens is fundamental for reaching an adequate diagnosis, patient follow-up, and definition of prognosis.

Keywords: Double immunodiffusion assay; Endemic mycosis; Paracoccidioides lutzii; Paracoccidioidomycosis.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Geographic distribution of Paracoccidioides lutzii in Espírito Santo. P1, P6, P7, and P10 (in orange) did not report displacement or previous residence in endemic regions for P. lutzii (N = 4). The dotted arrows show patient movement only within the state according to change of residence
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